ID A0A2A9MPX7_9APIC Unreviewed; 777 AA.
AC A0A2A9MPX7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein {ECO:0000259|Pfam:PF13532};
GN ORFNames=BESB_002730 {ECO:0000313|EMBL:PFH37932.1};
OS Besnoitia besnoiti.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Besnoitia.
OX NCBI_TaxID=94643 {ECO:0000313|EMBL:PFH37932.1, ECO:0000313|Proteomes:UP000224006};
RN [1] {ECO:0000313|EMBL:PFH37932.1, ECO:0000313|Proteomes:UP000224006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bb-Ger1 {ECO:0000313|EMBL:PFH37932.1,
RC ECO:0000313|Proteomes:UP000224006};
RA Schares G., Venepally P., Lorenzi H.A.;
RT "Genome sequencing of Besnoitia besnoiti strain Bb-Ger1.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFH37932.1}.
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DR EMBL; NWUJ01000001; PFH37932.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A9MPX7; -.
DR STRING; 94643.A0A2A9MPX7; -.
DR VEuPathDB; ToxoDB:BESB_002730; -.
DR OrthoDB; 47845at2759; -.
DR Proteomes; UP000224006; Chromosome i.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF2; NUCLEIC ACID DIOXYGENASE ALKBH1; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000224006}.
FT DOMAIN 489..606
FT /note="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"
FT /evidence="ECO:0000259|Pfam:PF13532"
FT REGION 47..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 546
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 548
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 601
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 777 AA; 82772 MW; 0796AD65D7178D58 CRC64;
MARCSRVEAV SAASGVDVFK QTETILRQTP WESLLLSQLR RLIAETKDAQ RPTLPPHSSR
RVGREPCGDR NAAGHEREAT SEETVGNRRR APRGTHANRA REGENSNETS AHADRGESDA
GWGSPGNDSR AKPQGVMEIG NEGDCKLAVI GGFPLRQQTL EFDSPQIRML LEGSRNLASV
QPDDHPDANA SRRPSPLSSS ASPRPFVASA PSASHAGSAS PSPDNSSDAV APSGGLLSPS
SARLFAGLSP AASVASAAPS ESGQVRGKGE GTELESVGAP SSLRPASDLS AEKVKDVHSD
AGHSPLDDRS APVSIYEVVP GALFLPAYLS VSEQLCLACE CLSVYSMPPH VCNLCNLIHS
SAEPSVAGAS SSSSHFSSEQ AGREAQACAD GAQGEQTETA EAEGGRDVIC RRREGETPSQ
EAAACRRFDG NLSRASLSPF LKKQLRWVTL GRHYDWTKRS YDEETNGVGR CPSTRPLLSS
FPTSAGATPA ISPSFAKLPA ALEKLCDDIL QLCEPYLADA REGTSRRVMD AAILNVYRSG
DRLRGHKDDA ERAEEPLVSI SIGQPAIFLL GGDSRQVAPK ALVLRSGDVL VLSGVARWAI
HGVPKLLYYN PVISLPAPRR RKKLRAHAST MQGGMRMSTV GLQTQMYEWR CSEDRQSSEG
VVCAARNLVA AAGLSGFGEL HADSGMRLLA TCTRRGGRTN SGSSSWLQLL EVYRRQTGDC
RHDSGDIRSG TGLNGHATST SDQTEPLEKI VGSQTANDVV SWLGELRLNL SCRCDES
//
