ID   A0A2A9NUK4_9AGAR        Unreviewed;       312 AA.
AC   A0A2A9NUK4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AMATHDRAFT_142821 {ECO:0000313|EMBL:PFH51342.1};
OS   Amanita thiersii Skay4041.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Pluteineae; Amanitaceae; Amanita.
OX   NCBI_TaxID=703135 {ECO:0000313|EMBL:PFH51342.1, ECO:0000313|Proteomes:UP000242287};
RN   [1] {ECO:0000313|EMBL:PFH51342.1, ECO:0000313|Proteomes:UP000242287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SKay4041 {ECO:0000313|EMBL:PFH51342.1,
RC   ECO:0000313|Proteomes:UP000242287};
RG   DOE Joint Genome Institute;
RA   Hess J., Skrede I., Wolfe B., LaButti K., Ohm R.A., Grigoriev I.V.,
RA   Pringle A.;
RT   "Transposable element dynamics among asymbiotic and ectomycorrhizal Amanita
RT   fungi.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KZ301989; PFH51342.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9NUK4; -.
DR   STRING; 703135.A0A2A9NUK4; -.
DR   OrthoDB; 2232005at2759; -.
DR   Proteomes; UP000242287; Unassembled WGS sequence.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000242287}.
FT   DOMAIN          13..128
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          155..222
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   312 AA;  34239 MW;  9CA3DA1C2242AD98 CRC64;
     MDSEPTGKGI LLKAEPIAAT FIDEVRNTTA KCAQPPRLVG ILATSSAPSK SYADFTRKQC
     EELGIEFVLK KTGAALSGEL AEGEGVEEAI IEANGDDAVD GIMVYYPIFG GQQDHYLQQI
     VSPFKDVEGL HFKFHYNLYH KYERLSLSPP PGMVKSIIPC TPLAIVKCLE YISVYNRLLP
     YGDRAYGRTV TVINRSEVVG RPLAALLAND GARVLSVDID SIQVCISTSI YYPRHVVHPS
     TLTLQECLAI SDVVISAVPN PAYKVKTEWL KDGCICINVA GDKNFEKDIR EKASMYIPAV
     GKVTILMLLR NL
//