ID A0A2B4R9R7_STYPI Unreviewed; 2300 AA.
AC A0A2B4R9R7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN Name=nphp3 {ECO:0000313|EMBL:PFX13553.1};
GN ORFNames=AWC38_SpisGene22354 {ECO:0000313|EMBL:PFX13553.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX13553.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX13553.1}.
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DR EMBL; LSMT01000947; PFX13553.1; -; Genomic_DNA.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 9.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13374; TPR_10; 4.
DR Pfam; PF13424; TPR_12; 11.
DR SMART; SM00028; TPR; 26.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 13.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 42..75
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 84..117
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 168..201
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1114..1147
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1156..1189
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1240..1273
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1282..1315
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1366..1399
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1408..1441
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1534..1567
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2023..2056
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2109..2142
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 2234..2267
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 362..424
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2300 AA; 261087 MW; D52C380A2A382A82 CRC64;
MSYNNLGLVH CQLSDLKQAK DCHERVLDVR LKKLGPEHVD VATSYIYLGL VHKQLGDLKQ
AKDCHERALD VWLKKLGPEH VDVATSYNNL GIVHEHLGDL KQAKDYHKRA LDVGLKKLGP
EHVDVANSYT NLDLFHEQLG DLKQANDCHE RALDVLLKKF GPEHVDFAMS YNNLVLVHRQ
LGDLKQAKDF YKRALDVRLK KLGPEHVDVA MSYKNLGLLG LRTIFKQEWD NRYKATLGEW
KDQPKNGMDF KSHESPGNRR KNALLFKTII NGDRAEWDCT MLFYAILYSD CICNLHPAVQ
SNVDVLRKFR NEDFAHRPRG YLSSEYFQDA VLKVNTAFHA LGLPTQQIRE IQTQTSFPTR
ELRNVLKKVD NLQQEVIEKE TKLQEKEREL QEKASQLDEK DKELAEKETK LVEKENQRQT
LEVQLQTKVL PFCILPPGPT HDVFPRRSEV DKITQHLIEL KDANHDSLST LYLLGNPGSG
KSQLARLAAK RFFDKSKETP SAISFVMTLN AESSETLLES YVSFARHCKC PDYSVTETRN
SKDLSTDEKI ASLKTLISAK IELYTSWLLI VDNVTSLSHV HTYLPGPENQ QWARGQSLIT
TQDTKSIPLK SSFIQHISVS KGMLPDDACS MLRLLSGVTD DEIEKEIART LEYQPLALAT
AAIYVRQVRD SKIASKFSWT DFLKKLEKGQ RSTIENILAE TNPSYPKTMT TATTLALEKI
MRSDTALDHL FTFLSLCVPQ PILKDIVVDY IMEMEEQLED KDAIEVKISR CPLLLFDREE
SGVYIRVHGV VHDIVNSVTK KSAKDKQIKS ILGAVSSFSK FEDQDSLVIG TKIVPHLAKV
ITEAEHFFSE DGLSQVAQID MFTLQDYSNV FTTLGIMCHE HSQYPAARSY FTAVLAILNL
RDPSPENQQW ARGQSLITTQ DTKSIPLKSS FIQHISVTKG MLPDDACSML RLLSGVTDDE
IEKEIARTLE YQPLALASAA IYVRQVRDSK IASKFSWTDF LKKLEKGQRS TIENILAETN
PSYPKTMTTA TTLALEKIMR SDTALDHLFT FLSLCVPQPI LKDIVVDYIM EMEEQLEDKD
AIEQLGDLNQ AKECHERVLD VRLKKLGPEH IHVATSYHNL GNVYRQLGNL KQAKDCHERA
LDVWLKKVGP EHVDVAMCYN NLGLVHQQLG DLNQAKECHE RALDVWLKEL GPEHVNVAMY
YNNVGLVHQQ LGHLKQAKDC HERALDVRLK KLGRSHVDVA MSYNNLGDVH RQLGDLKEAK
DCHERALDVW LEKLGPLHVH VAMSYYNLGN VHWQLGDLKQ AKDCHERALD VRLKKLGPSH
VDVATSYHNL GNVHRQLGDL KQAKDCNERA LDGWLKKLGP EHVNVAMSYC NQGLVHQQQG
DLKQAKDCHE RALEVRLKKL GPSHVDVATS YDNLGDVHRQ LGDLKQAKDC HERALDVRLK
KLGPEHCYVA ISYNNLGLVH QQLGDLQQAK DCHERALYVW LKKLGPEHVH VAMSYDNLGD
VHRRLGDLKQ AKDCHEGALY VRLKLFGPEH VEVANTYINL GAVHNYRGHI QKAKECYDLA
LAIYVKNFGP EGGEYGSSRP RITNCSEAQK VVDLVGRAER TLESRQDDIT SKNRTRFEWA
DEVGVVMKFS KRLFVPRLRE IFKQEWDNRY KATLGEWKDE PKNGMDFWNG ESPGKRTRNA
RLLKTMTNGD RVDWDCTMLF YAILYSDCIW GINPTVKSNV SHLRIFRNEE FAHMPRGHLS
SGDFQNAIFK LPAPGNQQWM GGQVLIITQD TKSIPLKSSF IQHISVSKGM FPDDASSLLR
LLSGVTDDEM ENEIARSLDH QPLALASAAV YVRQVREEGI SQVAQIGGST LQDYSNVFTT
LGRRCYEHSQ CPAAKSYFTA VLAIIELRDT NDELVKTDIH SDLGLVHWQL GDLNQAKYCH
ERALDVRLKN LEPEHVDVAM SCNNLGLVYG QLDDLMQAKD CHERALDVRL KKLGAEHVAV
AMSCNILGIV HWHLGDLKQA KDCHERAVDV LPEKHGPEHV DVASSYNNLG LVYWHLGDLK
QAKGCLERAL DVRLKKHVPE HVDVATYHNN LGGVHQKLVA GDLNQAKDCH KRALDVSLKK
LGPEHNDVAM SYHNLGLVHW QLADLKQAKD YYKKALDIWL KNLGPEHAHV AISYNNLGLA
HWRLGDLKQT KDCLERALDV RVKKLVSDHV DVATSYNYLG LLYWQLGDIK QAKDCNERAH
NCLKMSSSEL VTVADTYKNV GVLHIYQGQI QEAKECFDRA LAICINTFGP EDEKVRVVRD
TLTRLHQERE RTCGPEPVRK
//
