ID A0A2B4RGX5_STYPI Unreviewed; 1281 AA.
AC A0A2B4RGX5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000256|ARBA:ARBA00021888};
DE AltName: Full=Protein lilliputian {ECO:0000256|ARBA:ARBA00032149};
GN Name=AFF4 {ECO:0000313|EMBL:PFX16871.1};
GN ORFNames=AWC38_SpisGene18831 {ECO:0000313|EMBL:PFX16871.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX16871.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and
CC segmentation. {ECO:0000256|ARBA:ARBA00024653}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX16871.1}.
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DR EMBL; LSMT01000512; PFX16871.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4RGX5; -.
DR EnsemblMetazoa; XM_022948595.1; XP_022804330.1; LOC111341610.
DR OrthoDB; 2913847at2759; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF17; AF4_FMR2 FAMILY MEMBER LILLI; 1.
DR Pfam; PF05110; AF-4; 2.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Pair-rule protein {ECO:0000256|ARBA:ARBA00022788};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1001..1266
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 139797 MW; 34481BDB91E8A505 CRC64;
MSRLETDLRS TGFHSRGMSS GLAIHERERK EAQQERAKLR RQPSNTGNLP LFAEPRKVQP
SAQDALQQKI QATLGTYDTI APVLQHHNHL IGIPRLPPTP VEGQKFVFDR HKAKDAKSSP
KNHKLNGVIN SAGHLATKSP LTKSNNTIPP SRNSTLNLSK SPTLSNEAIT SKSADARKVL
SNIKSPTVKE AAVSKQTNSK KTLTHLKSPP GKEATTVKAV ESKKTSSQLK SPTLNNGTLT
KSAEMKKTDM KPVVNGNVKP RQNVEKEKDK SVTKVKGIKD EKSLPEDLNS DLHKGQNQKS
NPASKGKPPK IKLSLPDRNL PVSSVKQENL SMSDHPTNVE KIIEEMQQVA PPLTGIHTPI
KGGSSIFAFH RNSIQEPSVL PVLPTKRKPS ESTEGKKDSG NDVVLLDDDL VLTDDSDDEH
DNPVTHTSPS KTERNAHRRS HSTSSSGSSS DDSDSDSSDS DSDSSASDSN NNTKDKPRKS
PVHVASSSPK HTSGRNWGLN HIANALNQSS PSQTTKTKPS PSAANTVGGD GVRGNQVAPA
ANSNMSCLNS HVARSPVAAA SEDSFLSFAE GLFDLSSDLK NGVDIESLTA KLDLPLPAEM
SEGSAEPVSA LPVEDSATTL KTQQPKNDKK VKRRSSNVES KLNTSQEKGP TKYSPKKPAN
SKKTDSVKNS TNLKVSNGCT DDSAKKVTKT TKTPNGIVTK KSFKKISETK GVSKTSVSNE
AVRETSEVVD DEDIFVDIVS IEPSPGSDNK KVEVKQTAKS KETENPKGVK KKPVTTNGLS
KHVNGDGLLS SLISTNGTKD ILGKNVEITY DEVNKPESLI VKIDLSLLKR IPQLASNIPP
KHSVLSPTVE TNGSRDAINS PEVKIPKRKL LDVKPVEQEV SKKVKSNSED ANSRTKPHEQ
SLSSSGNNTR PPKDGTRKRS PSQEKDSHRI KRQKQDNENS KDHDSSPGFQ NGSVNENGMD
LVDNGVISHT CLCNKTSNVE KKREVDISRF YDPEPKVPYG PDHYLAEAKR LKHKADSSTD
KEAKAFLYVD AVLNFARCGK AIEQNECNES ESRSAFQMYS ETLDLLRYTM RNFVNRYTHR
SDRVPDKRLS VLCMRIQSLL YMRLYKLRKD GVMRNVKMVA EHFKGPPKST QAPSPYTSNT
KTTGTPSPLS PTPSPSGSIG SVGSSGSNET MTTPSRNSKP STGSNAITSP VNVCIPQKIH
SMTQQHILQV NNLVYSQDLW DQAQPLVLEF RDFFMDLDRN CGPLTLHSSI VHLCEYIQDG
LRRLQELLQS EKASNCKAAV E
//
