ID A0A2B4RKB5_STYPI Unreviewed; 904 AA.
AC A0A2B4RKB5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Mitochondrial Rho GTPase 1-A {ECO:0000313|EMBL:PFX16808.1};
GN Name=rhot1a {ECO:0000313|EMBL:PFX16808.1};
GN ORFNames=AWC38_SpisGene18898 {ECO:0000313|EMBL:PFX16808.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX16808.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}.
CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC {ECO:0000256|ARBA:ARBA00007981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX16808.1}.
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DR EMBL; LSMT01000517; PFX16808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4RKB5; -.
DR STRING; 50429.A0A2B4RKB5; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01893; Miro1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR013566; EF_hand_assoc_1.
DR InterPro; IPR013567; EF_hand_assoc_2.
DR InterPro; IPR020860; MIRO_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF08355; EF_assoc_1; 1.
DR Pfam; PF08356; EF_assoc_2; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51423; MIRO; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1..158
FT /note="Miro"
FT /evidence="ECO:0000259|PROSITE:PS51423"
FT REPEAT 674..715
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 829..862
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 904 AA; 100539 MW; 2B260C87E20B5B36 CRC64;
MTAQVGKTSL ILSLVSEEFP EEVPARAEEI TIPADVTPEK VPTHIVDFSE LDQSEDMLID
EIVKANVVCV VYDVTSEESL ERITSFWLPL IRQTGEEDSS KPVIIVGNKS DLMEGSTMDT
VLPIMNDYTE VETCVECSAK DLKNISEMFY YAQKAVLHPT APLFSAETKE ISDKDNDGLL
SDNELNEFQN RCFNTPLQGQ GLQDVKNVVR KNVEGGLQDG GLTLRGFLFL HTLFIQRGRH
ETTWTVLRKF GYGDDLKLRP DYLCPTIDMG ADQTVELSDA GYQFLIDLFQ RHDKDEDEAL
RPEELQALFG TCPTMPWGED VLSSVETNAN GWITLQGFLA QWALTTFLDY TRMLAYLAFF
GYVHQEIEAS LSTAITVTRS KAVDLQKKQT SRSVFQCYVF GPPGVGKTSF LQAFLGRTLE
PGELEKELSN YAINLLEVNR QEKYLVLREI EWENSGFLLH DRRCDVACFI YDSLDPASFT
QVIQLREKLP KTVPCMLVAG KSEGVAAKQD FEMQPSLYCS LNKLPPPQGY VTGGRDGVVT
MWDPLFEHCL KAFKVEDAAM NPGSVLLQNL PPVRALHTDE GKILIGTGND EGHGEGEVWG
LDTHPADDEC MTVSDDKTLR VWDLTKLRLK KVKKLKKGGR AVAYSPDGIT VAVGQNDGGF
LILDAESLEK IVGFKDRKEG ISDIKFSPDG KLLAVGSHDN FVDIYSVRRG RRTGVCKGSS
SYITHLDWDT KGKLIQTNSG AREHLFHEAP FGSRKTISVP DIERLQWSTF TCVLGPTVKG
VFPPGSDVTD VNATCRSKDG GLLASGDDFG LVKLFEYPVS HRGARARQYG GHSSHVTNVR
WTYDDRVLVS TGGLDTAILV WDRLVVSEVD EPDKAAEEKV LVQPKFIPTG PIKNPIARGK
PQWD
//
