ID A0A2B4RL51_STYPI Unreviewed; 2118 AA.
AC A0A2B4RL51;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0000313|EMBL:PFX17533.1};
GN Name=Pkd1l2 {ECO:0000313|EMBL:PFX17533.1};
GN ORFNames=AWC38_SpisGene18131 {ECO:0000313|EMBL:PFX17533.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX17533.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX17533.1}.
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DR EMBL; LSMT01000467; PFX17533.1; -; Genomic_DNA.
DR EnsemblMetazoa; XM_022947604.1; XP_022803339.1; LOC111340715.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1052..1073
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1262..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1336..1369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1456..1476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1718..1735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1807..1824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1844..1867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1909..1930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..132
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1097..1218
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 353..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1560..1573
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2118 AA; 239011 MW; 330533A496AC4C37 CRC64;
MHKWRNSEPN GNDKYAEITK NEGLLNGVSG NDQKAFICEI PEECPDTFFD NSWYIFSYVG
KRWDKNRDIC QSQGGDLVSI ETEEEWKFIN DNIQRRRALF YHIGLVKRAG NWTWVSGGPL
TICKWSKGNP SGGDLAGILK QFPRNGPTQG VFSVVTPYIV YTPYICEMPR ATGENSSQGF
CRDHLGIPCT LEYGKKGWVQ NCTFTDYTCR LNCIVKSCDH VPNHNPNEFC GQCSQTYRPW
GDHCNDVKYD RSTRYQICNA TRCNMTSGEQ RLGTNQTCYC TGDQCNLKCN GIRCKQTCIE
RKSATSSAAA SALTLLPPPS PSPFTPFPSS SSSPVPSYSS LFSSLRSPLP SPSPLSSPTS
LPWPSSSSLP SSPPLQTLRS NPTSTTVYYG GSLAGGKKYR LALFITTTGG LWGMSAYDIY
TALPPAGGNC SITPPSGISL ESDSILSCSN WKSDNTPLSY QFQYSLGNDL YSVLYDGLNS
TIVTSWIPPG NSADNYTVKI NVTVTDKFGI SASPVHLTIQ IKPTQRVQPA SVNLMANNSL
FNVFIKKRNL EKAALIANSV LRSMSRKPSM DSRVINYIIG KMESLEVKNV VEILQSSSVI
GSALELLETV SPESLNLSLS AVGSMTSLLW SIAQSKDVAD IPLITKSAQN LASCLDSVLK
AAALIASKDF KSSFQEQGKI LVKISIKVLE KVADSVLALT VPDDNTISIT AGQLSMTLGR
YSIDRLSRRV IRGGRGQFIL PTESRLLVSR VHKTSFADVQ MLSLPFNPYT WDGTNERVGS
DVLSLHLKND KGELMKISDI SEDITIVTPL KFQEIPTEWS KYFTKKGDLS FHEIKVKYEN
TLLMLEIKPR DTTVHMFVYM RFGQRPTTQD FDLNATISHG EKCVWMPSAH EKKEDQTFCS
LNSQAPIQIL AEQPGKYFLG LKNYNATVNL PHKREKRSCF EGRRRKRSCN EVKDAPATPP
RSQIVSVVPA YDSTSDQNYS LKVSSGSCVH WSEELEKWIS SGCRVLAASD GFLNCSCNHL
TSFGGSLIVE PNPIDFEEVI VQFQNLSETG NVAVIVAIAV VFLCYMVVLV IVWKIDRKDA
KNGGLLIHLP SSSNGTFEYE IVITTGIWKN AGTTARVAME IYGSGGKSGI FQLSQEEPGV
VNMLFSRSNS DVFVLSLNKS LGSIQAVHIG HNNFGNNPSW FLEEILIRDV QSNQSWKFMV
SQWFALERGD GRIERVIDLT STRLGFVSDV ARRWRRGLTE WHIWVSVAAK LKQSRFTRVQ
RLSCCLSVLL TSMFANAMFY KLGGKYEQPI QVGPLKMSGR QVVTGIESAL AVAPVNIIIV
LLFQKGAEKS YTNNGYCLKG IVITGIAWVL LLCSCIASSA FSIFYSLIWE KTVSEQWLSS
MLISFAQDLI IKEPVKVFFT ALLLAAILKI KNKRSTEHAR KNSQQVKSRC SKQRFWTLKL
SEVEKMRKCQ AKKQNLSRYF TELAIYLVFV FLLMIVCFGN RNDHRYLMKK SIWDGLANFK
KVANNTMYWS WLQNVFLPGV FSGRLYNGQE EKQTIYIGDK HSLLVGMARV RQFRVKSTQC
KVLKFMDTLF RECFEGYSTK NEDKTAYNKP GWRPLDNATR NDELLLLCPK PWRYQHAEET
DIVPKWGQFS FYHGGGFVAD LGYENHTGFN IVTSLQNNGW LDRHTAVVLA EFSTFNPSVN
ILGVATYFYE IESSGLKAAS TQISVLFLHS TDTTWHKFYL ICLFLFIVLV FLYSGRGIFR
IYNYRSRYFK SKWNWVEIFQ LVFSLLAVVM HIMRQIKVTS TMRKLRENIY ANIHFQEAIT
WQQAENGVLG ILMFIVTTKL LRVIRFNKHV VVYSKTLKIS WRSLSSFSIV LLTLFIAFLH
FGVLMFGSVS ERYSSVLKGA YFQLEITLGR VKARTINELA EANTIYAKIF AFLILFTLSI
LCMNLFIAMI NDALLEAKRN VNESELHELT DDDICSSSKE RGGFFDAISK TLKQWTVSQT
CEKEENSELE NVGIHFKKSS TFNFDEISQS TELLREEIAR EKTEEHRCSI RRQSFFDNIS
SMLKSAKCEN NNECGKGKEK KKVRFQEDVI ESSFRKLRKR KQDLLQRLNR IVSGFSEEDR
EFDDLLKAAE AQNYWIER
//
