ID A0A2B4RLT6_STYPI Unreviewed; 3025 AA.
AC A0A2B4RLT6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0000313|EMBL:PFX17783.1};
GN Name=Pkd1l2 {ECO:0000313|EMBL:PFX17783.1};
GN ORFNames=AWC38_SpisGene17876 {ECO:0000313|EMBL:PFX17783.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX17783.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX17783.1}.
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DR EMBL; LSMT01000449; PFX17783.1; -; Genomic_DNA.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR Pfam; PF01822; WSC; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 5.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 3.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 3.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..3025
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012021590"
FT TRANSMEM 1998..2019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2207..2227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2247..2268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2406..2434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2454..2473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2538..2559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2801..2821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2841..2866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2886..2910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2930..2952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2989..3014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..184
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 905..986
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1014..1075
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1080..1558
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 2044..2161
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 2374..2396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2499..2522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2374..2393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2652..2665
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 3025 AA; 340448 MW; C6827E3D72EAD7AB CRC64;
MLPFAIVLKQ IFEVVIVSLL DNLLLGCYEE QNNELNLHRQ KSTTLSPYKC IETCAHARFP
LAVVLNVTEC HCANDSFLPM IMKYPCSSPA AARNILLYNT SCLSTASVEI YQGLTFTAFT
SKMTPSVSSP VTQSSVTASN SSSKSLLYLI DFGDGKSNKT WREGSILRHH YVTPGEFNII
FVASRGNLTI FILSRKIRVS FVQVNGTWCP PVEPLTYLYC NAYNFYGGGV TAFISLGSLN
QTVSLSIPDM VFKKDLETSE FLNGHFFSKI YRAKLNRTSC SRYRGVKSSC GEWVPSSDRC
KKVCFDVRHW RYKSIMPCGQ RRSNYLKVYS VEANLTAGHN LIVIPKGQWF TADVGDIVGF
YRNSSGAELT QITAGKNGSV YFMPARNTFD ISVDLSRAQP LELSFDIKLY GSIRVAAAIF
VSCLEKVGLY PLITTFANAI SSHKVIAFRS LITVQNSVAH VRLLYEEFIK VNTTTNITAR
VEQGTNVTCE WYIPDSSLTV RQSPYLENNN TTEGGVFQYS SSYSYLGYVY VKVTVTNLVS
QKRKSDNIIL SVRQSIKGLR ASVCHNAFAF ENAETCMVSN ATQGSEVGCT WEFGPDDYTA
REMGKTISHV FTPGGPTNFT LHCYNKISKS SVPHTVQVIP NPLSIDAPLK VPAGVPVKIT
CLVNWPGGTP ALFFEQHGLK GRRGSDIVAD PVLTLRASGY SNSSKGNVTM YKSFGRALHR
RYRITCKSNS YPDLNIVHSL RAIYSVKGIN ITSDCALQAE VGTKCKFHVH LLRGDFPVFT
WKIRESDNYS TVSKGRKIVH RFVNTGFANI TVNASNDVSF RTKTVQFFVY STHTQSATAT
ESPSRLVYQS SIMSTSTSPL HASDSLSGVI SSYSTYSEEA VMSIRPSSVT FYKSASVDRH
QIPSLKDIIL RHASVGLVGH AIDFSVELVT NPHLVRFIWN WGDRSSLEEA GSTLSHTFYH
PGQYFITVNI TSTVDHVVLS GHVTVQYRLI DLHIRDLAVT SSNLLVLKFE ILQGDNVTYS
LKYGDNTEAQ VGFLRTLPDF VTVAHQYNER GIYRLSITAT SAVGPDISVQ RSVYISEIPC
VIHELRMLGA GDNSSQCPEI EQENEYSLYS SLKINCSNYG ELEYKWKIEN ILNDALTKVV
HLSKEVLSSS ALLLESQSLR SGLYKFTLLV TAKPLGLSKS AIGFLRVRMP KLLAVIDCGN
KRVMPWNQDI VLNASSSRDP NDFYDSRGKS SLSFEWFCDN NRSVSCFKES IDNRGPALVF
PPKYLDLNRT YRFVVVLTKG SRKAEATQSI EVVSGSFLPL CVRCKENCAH KLTPSKELIL
DGVGCQDDTN TTCIWELYGP PQANGRISKR SIGVQLIRVS YAKQFLLDPR NLISNRIYTI
LFTNNNSGFS AQYSVITDMS PTNGSCFVSP WEGQVIETQF IISCAGWRDE DMPLQYEFFL
GNPEQGPLLL YYGWTPYSNG LFLPPGLNDN DHNVDLFVKI SDALGSYRIV PLQAKVRSFG
AEADSVSSIL KGIVSGPDSM LEKLLEVGEF QQATQLMTTV VTVLNQVSSQ EHFSDSTEMG
NRVEVRRAVI AELSQVCCSS PQSIQQALGG LLQAIGVTAE LSPEALEDGA IALSNMAEAL
VIKFKSFQAA NESRDIIRGL NIILEASVST SNEVKRQQNS DEIKDWIDDS NEARNKDHQE
KCEQATTKSL KGINYAAQKL LDYQRNGDPP NHVSSSLMKM TLTRQSPSDI NDAALNGGVV
TFKIPEELKK DRLGAFNTVN TKVITMSQTP FISNDATPID TPVSTLEFLE TSGKEIQIQD
LAEPVSIFLS LNQTDIKDRN NMTGIIDAKE NITIFKIDSD NKSALYLTIN CTGVMSGHKL
IFTGRRNSKP RTDTFDFRWI IASCNTTLKR LIARKYLNTS ERLYLGVKLQ TKSNATNITA
ITSRIRYQVS VMAVGCYYWN EKMQAWTTDG CEVGSLTTPE RVECRSNHLT WFGSRVFVPP
NKLDLNLIAS RISDPSNYAP VLSVLCVTFG LYFLILVWAR RQDQKDKNKT GLTLSPSNRP
GDEHAYEVVI CTGMRRHAGT TANVAMTITG ENCESHAFLL RSSHRVTLAR GSVDSFLLTT
SETLGELLYI RMWHDNFGKD PAWFVKQISI REIDTDGVWY FVCERWLAVD EGDGLIDRIF
PVTSNKELNE FRRLFLTKAY NDLTDSHLWF SVVWRPPQSP FTRVQRVSCC LSVLLCTMMA
NALWYESDTG RYSAVQLGPF EFSWEQVSIG ICSSLIVFPI NLLLVQIFRH CRPEATRNHG
CFKPKPRQRF SSIKTEITMV KFGSREGSAL CIHSAGQSQS VNKCSPQEPQ KYYEDKGFSL
ASALRSAHFP ALSVSLAMES PPDSTSDIRS LLTRCSPSRQ SPTNDSEKSS NAPTAKYAPR
AKGLPWWFIY VGWFLVIITS LTAASVTLLY GIQFGLKKST QWLISMFFSL SQDIFVSQPL
KVVAFAVVFV YIFKKPSKVA FSPKSQLKFD EQPLQEQLQD SEEDFGERPE APPVEVPTED
SIKRARDRAQ KERMMHAILL DIGSFLVFTL LVLLIAYGFR DQSAFRQNDA VAKVLLQQSF
SGKPRESKPE RFTEIIRQRD MWDWMELAML QTLYNLPSYF YTGKAPTFIE GESGHVVGIA
RLRQHRTKRD SCRVVPQAQD FFSRCSSQYE MTTEEKQAYA TGWDSLSNNT KNSSPSPWRY
SSASDLDGYP YTGGIKTYSG GGYVLELSLI YYKALRQIRD SRTALWLDRH TRSMFIEFTL
YNPNSNLFCA VTFLMEVFPT GGVFPHSEVL AYRLYRYAGD FQLFILACEV FFLLFVLYFT
YREAKKIYKT RRRYFTELWN LMDLAVLMLC WIALSFYFIC LGLRKWTLHF YHQNPTKFIS
FQYLSAWQLM FENVVGVTVF VTCLKFIKLL RFNRRIFLLS CTLRHASKEL LQYFIVFIIV
FLAFSQLYHF LLASNYESFS TLIGSMQKLL SVLLGQFDLE EMMGLHKILC AVIFFLYTIL
TNFLFLNLLI AIIIESFEVV KRQND
//
