ID A0A2B4RME9_STYPI Unreviewed; 917 AA.
AC A0A2B4RME9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Glutamate receptor ionotropic, kainate 2 {ECO:0000313|EMBL:PFX17517.1};
GN Name=GRIK2 {ECO:0000313|EMBL:PFX17517.1};
GN ORFNames=AWC38_SpisGene18145 {ECO:0000313|EMBL:PFX17517.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX17517.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX17517.1}.
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DR EMBL; LSMT01000468; PFX17517.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4RME9; -.
DR STRING; 50429.A0A2B4RME9; -.
DR EnsemblMetazoa; XM_022947631.1; XP_022803366.1; LOC111340741.
DR OrthoDB; 2903680at2759; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13685; PBP2_iGluR_non_NMDA_like; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PFX17517.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..917
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012970704"
FT TRANSMEM 572..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 449..818
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 459..518
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 917 AA; 103447 MW; 6E28C62B6CD92921 CRC64;
MSASRTSLER SPFLTLLLVF IVTSSTHGVT EISIGAVFSK EPGENTTIEE QAFRLAIDHL
NEKYADIKLK ALVKSANPLD DFENIEKVNS LLSSNISILI GPMETSAVIA THPLCSRASV
PQIAPLTSLE MISEDGSGLN YLLRMSPTEK LKAKVIAGII ENYKWETMAV LGYQNKEAPE
GHSSFRLIAS ENEWNVVKAT LISPDPGGRE GDLLTALTVI TSLKESQSTR LVVVFFPAWA
VEKWMKLVKS KLDTDMGNWT WIFSNFGNRK EDLLSSDSGD IPNYMHGLLG IRPTVGKGTR
FEQFKNAWQQ QVPGKEISVS VGRVYDSVLV AAEGIKTALK NGVTLPRTQT YQGFCSSSDK
QEENTSGKDL AKYLNEVRVE GVMGTIHAND PDYAGSAYFD VVNLRSTGEY KVGEWNTTGL
HMFENEKPIW PSNSSDKPLD IPNILKGQTL KIATILAPPF VMWNNETKEF EGLSIDILEE
IRKRLEFNYN IYAVRDGRFG VKNRLTGEWN GIVKDIMDKK ADMSIAPMTI SSDRQTVLDF
TQPYMTFGLA FMIRVQEVNG NYFRFLLPFD KYLWVAICVL VTVMGFSVWF CSLFSPLGYF
GRCVQAKSTK QLKPEDLKQV DTLSLNNSIW SSWKAYVRRS AEHPRSWSGK LTVSVFWFAV
MIINATYTAN LAAYLTVSRM QTPIETILDL SRQTRIEYGT LKDSQLQTFF QKTDVPSYLV
MGQFMEQRKL WMPSFEAAIN RTLEGDFAFI SDRPILNYVA RQDKHCGKFK VTGGFGNTYG
YGFAFELNSP YTPLFNMELF RLQNEFIISS LTHKWTKERV NCELVDNFEE QQLLGSTVQK
MSVQNMLGVF ILLAISVLVG FLIMIMEWIY ASAKDARKRV QGRKTCCQAC GTRLIQALRD
MCCSKKKTTL DSDKTDY
//
