ID   A0A2B4RN92_STYPI        Unreviewed;       319 AA.
AC   A0A2B4RN92;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Alcohol dehydrogenase [NADP(+)] {ECO:0000313|EMBL:PFX19904.1};
GN   Name=Akr1a1 {ECO:0000313|EMBL:PFX19904.1};
GN   ORFNames=AWC38_SpisGene15664 {ECO:0000313|EMBL:PFX19904.1};
OS   Stylophora pistillata (Smooth cauliflower coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Pocilloporidae; Stylophora.
OX   NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX19904.1, ECO:0000313|Proteomes:UP000225706};
RN   [1] {ECO:0000313|Proteomes:UP000225706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA   Tambutte S., Allemand D., Aranda M.;
RT   "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT   digitifera provides evidence for extensive differences between species of
RT   corals.";
RL   bioRxiv 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFX19904.1}.
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DR   EMBL; LSMT01000339; PFX19904.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B4RN92; -.
DR   STRING; 50429.A0A2B4RN92; -.
DR   EnsemblMetazoa; XM_022943923.1; XP_022799658.1; LOC111337585.
DR   OrthoDB; 890110at2759; -.
DR   Proteomes; UP000225706; Unassembled WGS sequence.
DR   GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IEA:InterPro.
DR   CDD; cd19123; AKR_AKR3G1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044496; AKR3G.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000225706}.
FT   DOMAIN          17..292
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        50
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            79
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   319 AA;  35755 MW;  18E53A2499F5C249 CRC64;
     MASAAVKLNN GALMPSIALG TWKSKKGEVG RAVRLALQYG YRHIDCAHVY QNEDEIGETL
     TEVFNEGKVK REDIFITSKL WCNSQAPEDV LPACETTLKN LQLKYLDLYL IHIPLAFKKD
     VPFPHSKADG VIGYSPEGMA KTWQAMEQLV DKGLCKAIGI SNFTTKKTRT LLETARIVPA
     CNQVELHPYL PQPQLLKFSA DKGIVVTAYS PLGSPDRPSA NKDSEPVILE NPVLKKIAEK
     HGTTTALVAL AWGIKRNTPV LPKSVSENHI KENLEALHVN LDEDDMKTIE NIGIHHRYLM
     QTWMFRPEEV PENYWDGEE
//