ID A0A2B4RUA0_STYPI Unreviewed; 1398 AA.
AC A0A2B4RUA0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000313|EMBL:PFX19812.1};
GN Name=edc4 {ECO:0000313|EMBL:PFX19812.1};
GN ORFNames=AWC38_SpisGene15741 {ECO:0000313|EMBL:PFX19812.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX19812.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX19812.1}.
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DR EMBL; LSMT01000343; PFX19812.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4RUA0; -.
DR EnsemblMetazoa; XM_022944067.1; XP_022799802.1; LOC111337721.
DR OrthoDB; 2911539at2759; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 124..450
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 307..340
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1269..1388
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 22..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1398 AA; 152788 MW; 038602BE9FCD8E30 CRC64;
MDDNAKGMAS KILCDLLNIG GTETSNGNSL QTQRNGERDL DDSLSESAST ASSLSPQRRG
NSKDQMSDVS VSDSEGVASR MSLEPVKQVI EMKGSDDGSS KSVYGNEVEI VTGEAAVSTS
ATASNKIKFN SMVNYDWELK YYRGCLIAVS SKCIAYALRG RHGYVVRLLN PETASRTLIK
GFVGTISELA FSHKDSNMLA CVDEGGNVYI WVIHEEDGKL EYSVKLHIKR PSSTLSEHHR
LIWTPYMPDA EELERTEESA AEEGRPLAIT HGNQVEVIDV DSLTEWCGRS EVTIDDIKQG
AGYLEITDGH AMPITEGALS PDGAVLATAS EDGYIRFWQL TDNVECMHDF QPHGGHPVSC
MIFTDNQTSQ DKELPMWRFL ITGADYNREI KVWCTVTWSC LQTIRFSSPD IPGSSSIRSY
LKVGMDLSAS YLVISDVLKK VIYVLMFHQN FDEGQAHVTS VANFHLTHPL LSFIVGQVKL
FKLKSQGELN GEDNGESHDH DDDDIHSSHV GLKEITAGEE KGKKYGVQLQ LFCIQTRSMQ
ELLVHFQPEP SVPQPTPSTL SSLTTVAGQS VIHDALSDLS GVETGTEAST DVEEPEESTD
GPVPVRTKLI TPQAFESTVS QGSPHPEAVN SSSGSSITMI SGLNNSQASV DELLGSSVSS
RLSDSTVKSS NSATPQGSFS HENGILTPTS LHLPQSPVTL TPNPSAIPIL NFQSSPQMAS
VQNTQSPISS FEPLVAITNT ETQASPYTLG EKAENVLNDS KSPSEQNRSH SPGSKERNIE
VSVDDDARDE GEEELPESQK PEAETLEEEN QRDRKSSSGS STSESLRPLS ARAEGNLICL
DDDKRGIGDD VQVDGEDAFT EEGLLDQWDM NGDDGVVPTG RESPESAHAL PVGTPTGYNE
GRKQPSALSS FVSTPVSTTD LPPQQAKVTM DGGVLSSLEE LLSLVKAQQQ DICDLRKQLK
TYQSDQQQEM ITVVNEVHQV EERVSSKLQT TLDDFFREES QRLDKALRDK HSGDKKRHEQ
LQSTLSQTIT TTLSGKLDKS VKAEIKSAVV PAVQKVLSAM QEQLNTALAQ KLTAADTVLK
DSIGKIVKSK GVVDAIGTAA ASALQGPIQV TYREAFQSSI LPSFERACQN MFQQINDSFH
KGTQQYLQQV TTALDNRKRE EKHSFEPVMR QLESQKQSFQ AITERLSSNL MADFEVMIQK
QLSSSIEGLR EEIFSRLLSE VLASVQDSVQ KEMGLGLEGL RQQLKDMITA SVVNTSQQSP
TTAHTRVVVS KLLESGQVGQ AFQEALTVGD LNIVMYVCEN VDPEKLSSQS PCPLSQPVLL
SLIQQLSVDL TMYTDLKHKY IEVALMALDT RDAVTREHMP GVIEGLCQQL QAAIDEASGP
IQRSLKMLQM AARSLLVR
//
