ID A0A2B4RV69_STYPI Unreviewed; 713 AA.
AC A0A2B4RV69;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ERN1 {ECO:0000313|EMBL:PFX20218.1};
GN ORFNames=AWC38_SpisGene15361 {ECO:0000313|EMBL:PFX20218.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX20218.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX20218.1}.
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DR EMBL; LSMT01000326; PFX20218.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4RV69; -.
DR STRING; 50429.A0A2B4RV69; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PFX20218.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..713
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012134554"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 580..708
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 367..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 80903 MW; A02C12FD436CADFA CRC64;
MSRYTIFGLC LGLIFFVSWH SVVASEEART LSVPESLLFI STLDGTMHAV KKQTGDVRWS
LKEGCVFYYV LSGGLHPFGD QYRRQANIIA GEFNLEKIIN CEMFTEAKDL IRMMLKPSPS
ESAIFIPDPK DGSLYGFGSA HDGLKKLPFT IPELVRASPC RSSDGILYTG RKTDVWYAID
LDTGIKQQTL KLDGTETVCP IMSNKKAPVF LGRTEYMITM YDSKTREKRW NATFHDYSSH
LAQDVDYDLH HMCSSSDGFM VTMDESTGEI LWTKNYGSPV VGIYRMDNEA LLKVKVNHIA
KETLKHLIGA NTSSSSHQNT FLGDRGEIVL QPTLYIGEHA GGLYALPSLI EEGSPLVEAK
VLLIEGPRSG LPKTGNPTKS SDAVSAREHS ANTSPPVRRP IQQPKVLEPK AALLLGHHQV
PLVANPQLHI THIPDKLMPM YMHHHHLHNM KMAPKRIEKT TTKEEDRRQQ QEMFEMMKIH
QRLLYTIIAT IGIPVVLLVL FFIERSTRQS AVSSRRSSPP SSSSSSSQRV DEQTSEQSPD
ILTSISFLKE KKGCFRIPFA EGLRKPSAKG ILKHPFFWSR EKQLAFFQDV SDRIEKESED
AELLVLLQKD SIPVVRGDWK VHLGSELQED LRRFRTYKGS HVRDLLRAMR NKKHHYRELP
DHVKEALGSV PDGYMRYFSS RFPRLLMHTY NAMATCKSEP VFQTYYFQKV PLT
//
