ID   A0A2B4RXY9_STYPI        Unreviewed;       994 AA.
AC   A0A2B4RXY9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Metabotropic glutamate receptor 2 {ECO:0000313|EMBL:PFX21115.1};
GN   Name=Grm2 {ECO:0000313|EMBL:PFX21115.1};
GN   ORFNames=AWC38_SpisGene14393 {ECO:0000313|EMBL:PFX21115.1};
OS   Stylophora pistillata (Smooth cauliflower coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Pocilloporidae; Stylophora.
OX   NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX21115.1, ECO:0000313|Proteomes:UP000225706};
RN   [1] {ECO:0000313|Proteomes:UP000225706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA   Tambutte S., Allemand D., Aranda M.;
RT   "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT   digitifera provides evidence for extensive differences between species of
RT   corals.";
RL   bioRxiv 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFX21115.1}.
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DR   EMBL; LSMT01000290; PFX21115.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B4RXY9; -.
DR   Proteomes; UP000225706; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   CDD; cd06362; PBP1_mGluR; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR   Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR001507; ZP_dom.
DR   PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:PFX21115.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          648..899
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
FT   REGION          605..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..620
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   994 AA;  110195 MW;  36F2743112622276 CRC64;
     MLVVADNQQL QMDGDVLFGG LFPVHKRSTL SENVCGEIDP QAGFQYLAAM LFALQKINHD
     TELLPNVTIG AKIFDTCRSQ TIGADRAKDF IKHTLLDEPK PLVGVIGPFT SDVSVAVANL
     LRVFEIPQIS YGSSSVELSN KELYGNFFRT IPPDSFQAQA LVDVALHYGW TYVYTINSHG
     NYGKGGMSIF RQIARKAGIC IAKAESLPSL PREENYMSAV QTILRHKIGN AHVIVLFTTQ
     TDSAGLLRAG KESGVKGLTW LGSSGWSNRV DVTEGNEELA NGSLTVGHGD GIVNGFLDFL
     TNLNNSLGGT SYPKTDNLWF EEVVQSVLKC ETRGSAPSSL TACKSNLSTS LPRDIELAPV
     RVVVNAVYAL AHALDDMQRD LCPKQTGICQ QMKETLKKRS LIGYLKNVTF PDASYNLTLK
     FNENQEMDGT YSISNFQQRE DGSWKYVRVG TWRYLGDLAK DKVSELGIDN SLVSWGNAVT
     RPPYSYCSDS CTPKQITKPR ILNSECCWNC ISCQVNEVII NNTCKACDLG YKPNPSLQKC
     VKLELSHLQW NDPISTSLKA LVVLNSDMKT VLLLLILAVT HVAVTSYIFE TLEVARRDEE
     EFVNNQDTGT DVRRADPLGD RTGILSDGPS GEGEGSGVSP PDEEVIVTCG QNEMSISIPK
     SLLNGLDVEH IRLTDVDCGA TENPARDRYI LQTDLTGCGT SSRHIRNFVT YMNKVEEIPV
     EDDQVITRVR EVEIPFTCAY SNTGVVSAVG LQVESKKIVF SEKGMGKFVL EMKIFPDDSY
     EGQYTKRDFP VTVPLRKVLY VQVSVDTDDS DLAILAETCF ATPDANPNKE GLKYVFIKDG
     CSEDDTLEYK ESSDKRRQRF SLEAFKFLGD NQFVYMHCKV KICDANDTNS RCAQGCLRNS
     RRRRSLYTQE TNDDEYLLAQ GPFMRGTEES DDTDSQVDIE LHEIENSGQL TPLVAAMAVF
     AAVCVMGVSY FAWNLKRKRR VVRGYQLLTA PTDD
//