ID A0A2B4S0I5_STYPI Unreviewed; 650 AA.
AC A0A2B4S0I5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Pancreatic secretory granule membrane major glycoprotein GP2 {ECO:0000313|EMBL:PFX22926.1};
GN Name=Gp2 {ECO:0000313|EMBL:PFX22926.1};
GN ORFNames=AWC38_SpisGene12564 {ECO:0000313|EMBL:PFX22926.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX22926.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX22926.1}.
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DR EMBL; LSMT01000225; PFX22926.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4S0I5; -.
DR EnsemblMetazoa; XM_022939275.1; XP_022795010.1; LOC111333651.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR45713:SF6; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00024; PAN_1; 1.
DR SMART; SM00607; FTP; 2.
DR SMART; SM00473; PAN_AP; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706}.
FT DOMAIN 548..640
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 650 AA; 71912 MW; 2D0DFA059ECCA9AA CRC64;
MKAFTHSIFI VQIPGAVSGF TPGEPSTVGE PLPLLAKILI PVVGVLFVVV VGVAWCCCVR
GKERENFENP TESTQMSDWY LNSPYNISPE SSIENSNFRS AGDWDADLAL RQPAKISGHG
ESEAALAVEG TSARCAVTSL LTDPWWRVDL GRSYVVDAIS ILTGAHALTD FEIRIGDSLD
NEGNSNQKFG GPYTTTSSQE KSFFCIPGIR GRYVNIRIAG DNKKLEICGM SVNPNPTGGP
QVFSYEVDKD VANLALGKSA SQSTVSHSAY PVRALDGNID GRFSSSCCTH TYTTTDPWWR
GDLGSSQYVS EVFIVNRVEA SYRLFNIEIR VAILKYKPVE HSVQDAYDQT SLTLVCPEPF
GYPEPLVAWV KDGVVLQNSS SDLTLNLSII IQRGITTWAI DCVASNKHGA DYYRFILNLR
SRREMCTEFR DLVEGTRTAH HVVHNQVLAQ NDNDIDNSIW YRFVSPATAT PVQLPDSCTE
PRTCGTQASG WLRGGHPSAE EGLVNRTVCF SWNDNCCFAE VPAQVKHCYG YYVYKLQPTA
LEVKARYCVE NQDIHHEDAL FHLLVSKTGV QLALTGHVIH TEYHVTSSWK CMAYCLIEVT
CVSFNYYPQS NTCELNNSTV SSNPESLREG PGTEYYERMN LISLEAGSHL
//
