ID A0A2B4S6S2_STYPI Unreviewed; 5161 AA.
AC A0A2B4S6S2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dynein heavy chain domain-containing protein 1 {ECO:0000313|EMBL:PFX24743.1};
GN Name=DNHD1 {ECO:0000313|EMBL:PFX24743.1};
GN ORFNames=AWC38_SpisGene10671 {ECO:0000313|EMBL:PFX24743.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX24743.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX24743.1}.
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DR EMBL; LSMT01000168; PFX24743.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4S6S2; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706}.
FT DOMAIN 1048..1515
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1726..1845
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2077..2176
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2442..2562
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 3205..3478
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3546..3820
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 4086..4262
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4542..4675
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4722..4844
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4876..5157
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 18..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..1876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2191..2215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2473..2492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2842..2868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2883..2910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2983..3091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3955..3984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4019..4047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3483..3555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3699..3751
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2853..2868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2999..3027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3032..3046
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3047..3081
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3969..3984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4028..4044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5161 AA; 579734 MW; DA2302B2DD48F9CE CRC64;
MSDQISEVAF SQPKLPAIGD SRSLVSQPTI TTSSGLSDTS DRERLSSRPM SSDELEDGDV
QILQQQVSRS FVNALQLNTK QSWYHLCEVL DIIKPYSHFL TGTPQIRHYV ERAYVKINAS
GDENDYSFVK EKLLAVFPNE LSAPHGGVRQ QAIPFPTETS VDSLFTPRGL QPSSYKGVKI
PRGVPIFPGG TTYMFDHSDG EAKSYGPKSL CMEDLKRALP GVVREIAIRE ATLGGSLGTT
ALALDIDLPQ THVPTPPSTP RRSPSFPVIR IPFSESGKVT QQSNVKRGML GKTGKEVVEN
FVKGRFLGQE NFAFLNVAPS LRYDPYNLVV VPEEKVNPEH YVISSHCVLH VNPVGPSETQ
SLAEWYREAC LFKAISSIGF FKNFVITKMF RKWKNIKKFS QFLKVEAEIE KSLISNVPSF
GSALIRISSL LQDLEKVTFL PFQINFSYSL GEFEDTIFKT CGTGHKYIEK FFSYCQMIIA
KTQESCFEYL EYCKGQVKSH RHNYQESLAV AKKKRAVRQH NLKLAQDEIK RLGTFVCLVD
RIIVSNLLKL VQKNISRFVD EAMLGPRPER DGLFSAKIVF GDDHKLTLSP SVKQFSHAVS
VAVGCVISAA CNLSHPMELG SNAKHFQEKA ENEADVQVGC SEPNDFVASD SMKQGLAKTG
DRLSDIEKLV FSSEKQSETL LTGGQQPMST KLNMTPHPQT LGRDDQDNAD TFGSPTTVTR
TDDEIYEDLD GLNSDLSIAR DMSGQATLQL CFRQEPNGGL LVEGQRFQDF AVEKSPLTKE
KLGEIMLKNK QVTEAIERQV DLLSQATEEV EQFCDDHSWV ATIHEFVSSW GNGETHEWRG
QLTSKIEQQL NQIKTWKEQV LSMAKSFCTQ NGIFFVDCHK VQELLKDQKT DIKGFSDFMQ
KLSTVKEHVS RLKEKVEYIK NLYEVIRSCY RQLTPEEEIM EEKVWATWES FLFGLQEASD
FVEVHKPQVS AKLVETISTL QRTAEEIGQL ATTGKFLDPN EKPSSVLQDM RELKEKFVGI
QNKLADLSKC QAVVLGREYD LGHITGILHA IEKRQELWKY CDSSSYTIRE WMQTVFKKMN
VKKAMDKLTE WAHAGEKLKN HIPEDDEVLV SWLSQLEEFS QDLPFLLQLS SDALKSRHWR
ALFIGMGQDY DPSWEFTVAN LFSFNLGRYK ELITTVCAGA AAEYALELQL YHLAHAWEEK
HFKLAKHIPL MRPRLGDKVR KAKGGRKTMQ PGAEKANVKL KPKTPASVPD MYILIGIGEL
KCIIEDNLVT LHIMLTSPHV ADLKPMVETW VTNLQEIESI TDIWADCQKK WLYLSNVFAE
PELRRSLEDS SQNYRDVDEK YREFVRVISR DPKVLSVLPL KKRGEKGWRD LQGDTLRELL
LELTRKAEEL IKMVGEYTDK ARVVFPRLYF LSDNDLLGLL AWSRDPKDLL PFVRKCFPGI
KKLQFALPRD SSLRLASTLD TALNAHLLQV TAMEGVLEEV VPLLSVIPAS PRPQSWLVTL
EERMRNTLVK SLAECVDRRL RGRESPRKIL DLITSFGEQV FRQTSNSVND SKQTSKEEQN
DGSEAGQIFL KFPSQCVVTA EAVVWNMKMT EVLQNRNLQG LSNLRKSLVS YVDDLAQIIR
KTLENESSTP AHGRLELLLF ALVGLVINQR DIATEFVNNG VLDVNSFEWS SQLQHHIEQN
KIITSRYQGE DSGENQISAI PSTIPVEHFY EIGLCSLHQL GTSFAYGYEY LGPTPRLVVT
PLTQRCFLTL NMAVRSHQCG VPVGPDGIGK TETIKDLAKT LGRHLVTFNC SEQPTTSMLV
RYLFGMIRSG SWACFENIDC VEPGILSILG EHLASIRTSM KSLEKFVVSQ YTARGISKTD
NPESETGKRR NSVTTLDSLP QEAFSPSYRP ESKSGSHVAK RKRYLSITRM YDLEGGEYYE
NETQQTYSPM EQQPKFPQTF HDKVAKVYKK QTSFREFEMP LLGNIVFVGK LMAASAMYGC
FMTMSGKNCF SADLPENFRA QLRPINTFYK LINEQVSSQP QYSFGLRSMK MVTTLAATEL
QKEIASKRRS TISSLAEASQ SEAERKTRSP FLETLERRQA EENAVVQAMF LYFGKKLLGK
DKDLFSRGVD EVFAHSVLMS VSTEGDSKLV EELKDRLQTN GMQIRQELVS KIIQLHTTLQ
TSRNVILLGC PGSGKSTIYT TLASALNSMN SQSTQPVVKH RRQAGTERRM STSFRPAAKM
PVEEIKDVQR PRVDLSVVFP KSLTCEELFG RQHPETGLWM DGLVSKWLRD ATLTCDTMAD
LLSSQSSEKQ RIARMMGSLS HVKKWLVLDG PMDDTWLESM GTLLDSTRAL SLPNGESIAQ
PETVTILFEV TEINHVSPAL VTRCGLLYCP QSLVGWKPIF RSWLRGAHAR WDITNRGLGI
ISCLMDHVVD STLDFLSQHC EPILTSGYSS INKPSKTAAG VHEVQSLLRY LSAIYDRHIL
REDEDSQIQI IKQRNRQTSG SSGSSGHSSG ISASDTGRVV SSFAFAFIWA FGGHLHKRYV
EKFDEHARQL LSAGPYPFLI PPDGLVYDYC LDFSKGGLVK WEGRPGSQLK TLPSSYTVIT
ELDRYFYLID LMLSAHQPVL LVGPSGIGKS SLVQNLINPR YNSTRICLSA GLTSKLFQEA
IEHSLQQIKR KEMSQLAFTK AIPGAAPPKN PPVTKSRTQF MFLDDLNYAA SDTFGIQPPL
ELLRQILSQG TLYNKQRHYM YRVQHLQFMA ACVPPGEGTS CGGVASYAIS HRLSRLMTVL
SFFPLSSESL ETIYSSVFQA WLGEFPAYSL SHHEHLAKAL SSASIKMYNI IRRELRPTPL
HPHFLFTQHE LFRVAQGMSL LSSKSRGRPR PRVRRRADTE KDSEGEAKVE AIGAVKSESS
ILGKERSQRR GNVGKGRSWP SLTNGPIESG LSAKTPAALS PMIRSLLRLW CHESTRTYSD
RLLTEEQRYW FSSLLHETVE EFFCKTTSEL GSEVFSVEQS LMQKNSQDAL PGRDASPPTA
NDEQIQTTGK SEGPLQLDDS STLPGGEPQD LSDEGAGEEE DIDAIPNQET PDPREDIDAY
TTEKNVANDD IFPKEPNGND EILGEEEVPE DETLSREQSL IANTVVLQPA KAKVTFNDTS
GLSYDKKYDG PLISSEQLAF SGEDLTDIVF CKHFNVSVTG RESSASEVAS KNYLECAESI
LEQGIKRCLT SYNDQVAESS SAKIMSLVTF REAIHHAVRL SRALATPGGH ALLLSDLGYG
RRTLTRLTAH AACCKLFELQ RSQFQSQEDF RQQIKVASFI AGLQGKPVAL FVPEGVDDES
MQDICSLMAE GTCPGLYTHN ELSMISNQLL PGGKRGARRV ENQDIAQERY FRRVKSHIHV
FVCLKYKKLE LSNSLEKNQL YKFPTLVTRS CCVDVYRAWP HEALVSVAEK LLDEDESVLS
LVPLKRRERD LQSVAICSIM AHVHLSSRNM VERIYGVKAL KFYSPDTYLD FIDLFRKICR
RLCAKEKEEV AHLDKAIKRM DEATHSLNKM QRELDNLAPV YEASKTDIQL RQETVEACQN
EFTAAKERCK KQEKDIEEMQ IPIEILRKEA QVEFEKVNPL FDAAWKAIDS LNIHDLEEIR
SYRTPPALVT LVVNAICLMF EKEQTWEEGK LLLNRNNFFK DLEFYNMTDM QDSIFDGLKT
FYYNPLFQAD VVQDGSMAAK SLCMWVRAVY DFCLAHRGLK PKRRQLEKAE QELEEAKSIL
GEMRVRCNAI KQELESNIQR YKESVKHSRT VEKQIQNIET IKSKGVALVD SLSSYSNLWH
SGRSLAKQHL TSAPGDSLVA AAAVCYLGPL IPEARDELFA DWLRVCDGVF RAPPQGFRTL
SSMVLDDFRK ECKHLEEPDT RKDSRPATQS TLVSTIATNI VPVREGVSLK TVLSAPNELE
DWRRNDLPMT EQAVNNALIL RSCGDDRTRA WPLLIDPHNQ AELWIRALHQ GEAVDRAASS
RPDTRQSDRS SRPSGGSSVD MEASQTLDDA HLEQAPAEEF ESDPQLFDNE VDQFLQSLRE
NDDQESSFPE GETQATSRRE RTAGSALTGL SDKMLKDKLA EAMGIQIDST PLPISLGPSP
VLNLSEGQIL VVSADDPLLV EKLRAAVKKG LVTLVTHIER RRWNKTLELL LTRQTFTSTD
GNLQVIIGKT AVDYKPSFRL YLSSSLPLFI PGKGQCPLPL SKACTINMSV SREGICETLL
GDTLRLERPE LDGQLRSIDR DVGLHKQQIN NAKEVILDKV VSLSGPLLKD SAMLDAVTQN
KDMISTAEER CGEAELMKTE LLAKQNDFLP VAQHGALLFS VVSELCELHP YYRFPLESFI
QLFRDTIAER NRGKKSSGSP GARAAELITA LSRKIFDRIS WSLFQSDNHV FAFLLAAEKL
MNSGSVSRDE WQLLTKVLGR SEFDHSDESE VPKPPWVTQK VWESVSDLER LPDFNGLKRS
VAEQSHQWQE YFNLPPVLLS ATPGDYAHLT IFQKALLWKT FKLDQLFHVC QEIVLYQMGA
NMIRPVGYDL DQVYHVTGRS RPAVFLLPSQ NILEQGEANV LKDPVTDVIN LARARGKDTP
LLKVTLGERD SMEKTLTAVR RGINTGCWVI LENCHLATCW SDELMHEIET IVNSPVMDTE
RDSERHDMES NCDDRTKNGL TEDVVVHPEF RLWLTTRTDI GCPLPAVIIH RGLKLACEAQ
ENFRDAVRTN CQVATGSLNK CVPLWGEAAK ESVSKSDVPP SAIFTLAYLH TALLQRRKFG
HCSFSCPYKW SQTDLLAGLE ALRYLSQVSH GLLPPAAVEV MLGDTAYGGH VTNGLDLNAV
RSLTNSVTTE NLEMNAFEET STCEQVDTYV DDLPEALSCQ QLGLTSVCYS AYQLKLSSVV
ADRLALCTRH QPTTLSIENQ VKSVAEETLN KITNILDFIK SHSLAIEETT AIGSFIQREL
LYFQNLHESA SREIGLLINA CSGHVAFTPD LFNVALSLGR HAAPSGWLLG RARDISLARW
LEALESQVKA LCSYLLPSSL QPCSYCLGAF AHPQAFLACV LMDHARSAIK SVYVLEFSVE
ILDPNFSPTS PPDRGVFLKD LKLNGASWDG GRGCIIEAPK LHDVCDLPIV WLKPLEVIRS
RAPSAKVEKQ QSDLPVYNCP LFVEESWGEV ASALVTSLPL PTAVPEVLLK QRRVAIISHI
F
//
