ID A0A2B4S7R3_STYPI Unreviewed; 471 AA.
AC A0A2B4S7R3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Heparan sulfate glucosamine 3-O-sulfotransferase 2 {ECO:0000313|EMBL:PFX24850.1};
GN Name=HS3ST2 {ECO:0000313|EMBL:PFX24850.1};
GN ORFNames=AWC38_SpisGene10532 {ECO:0000313|EMBL:PFX24850.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX24850.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX24850.1}.
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DR EMBL; LSMT01000165; PFX24850.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4S7R3; -.
DR STRING; 50429.A0A2B4S7R3; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF73; HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transferase {ECO:0000313|EMBL:PFX24850.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..456
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 286
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 286..290
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 369
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 377
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
SQ SEQUENCE 471 AA; 53117 MW; B7866C9F3300C776 CRC64;
MRGSHSGHSK SKKSTQKSTI VEIKVGLAGQ TDGVIKLRRG KTQIITVNSL AKKEDIMQKA
KAKHASFDQS FDDTLQYTLL YPDFREVVNV PGTNETFQLS TYKQAIGKEF KRLTFYLIPG
DDFTDMSDES DSEAIANPAK QSHLCEFFSG ASNRDLTGSS DDGNDDKEIR EVDRCPCDAS
ESGTSYQAGD HRTERVLYEE FIPPEFQYHP SLHKLCRRTE LLQSAPIMAL PSRYPAIVLG
LFILGIFCTY RFTTWKSKSA KKVAKPQNVA ILKKHLPKAI IIGSGKSGTR ALLVILKIHP
DIKACPKEVN FFNRNENYKQ GLDWNRSQMP KSREDQLTVE KSPGYFTSMT VPRRVYRSSK
DVKLLVIVRD PTARAISDYT QLALKQNNSL LAKFEDYVTK EASVVDTKRS VVKNGVYINH
LRQWLMYLPF SQIHFVSGEG LVQNPAAEIR PVEKYLTRGQ FLEGPGNLMG P
//
