ID A0A2B4S8D7_STYPI Unreviewed; 769 AA.
AC A0A2B4S8D7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=Zdhhc1 {ECO:0000313|EMBL:PFX25349.1};
GN ORFNames=AWC38_SpisGene10048 {ECO:0000313|EMBL:PFX25349.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX25349.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX25349.1}.
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DR EMBL; LSMT01000153; PFX25349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4S8D7; -.
DR STRING; 50429.A0A2B4S8D7; -.
DR EnsemblMetazoa; XM_022935365.1; XP_022791100.1; LOC111330500.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd01644; RT_pepA17; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR47331; PHD-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47331:SF2; RIBONUCLEASE H; 1.
DR Pfam; PF01529; DHHC; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transferase {ECO:0000256|RuleBase:RU079119, ECO:0000313|EMBL:PFX25349.1};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 79..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 131..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 33..172
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 182..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 86072 MW; 17743F1B4962019A CRC64;
MALTLDPADP NIRGDTQKSK AIFDRSQHQH VIENCHCYIC QADVGPKSKH CSVCNKCVSD
FDHHCKWLNN CVGGQNYRLF IGCVSSAFVL AITVFTTTFY VFVMYFVDKE GIKSLTGGQF
KIFVEVSSDE AFVTFLGVIL SLLLLTIALL GHLLGFHIYL MYHKISTYEF IVNSRDSQAD
VTDVEAGGKS PSRRKLFKNK VKPEEDRREN AEPARIEISD HGRSEGSDDS LRVETTVKFI
SEVSSKAAAK NHRSSIEHKE SQGQELVSKQ PSVIKDYSPL GMMEPSGSEE SVKEITPTPP
RVAIHQPAVG NKASKLQRPA EIVLDQYGAD TASALPGPSR VTFADDEEGE ELVPSPRKKK
KRKVREGINS QTGNNEECEL VEIVTKEIKP GNVSNGQDTV DAPILKKKKK KKTKNASPES
LPPVVTRRPL PQLQLEVEPR SFTRSITNLN RRLESLQPRA SSKLFLDVAS TRTVSYIVRK
CLQSLIALPE RRSPFNSTME EETDGQATRR QVLPDVTFDQ QGVRNENLVR LRRSRHAQMV
PKTPLEHTAV VIWYLPHHRV VNPNKPDKVR VVFDCAARYN GVSLNSQLLQ GPDLANNLVG
VLIRFREELI AIMADIEGMF HQVLVSPKDC DTLRFLWWQG NDLNKDPEDC QMLVHLFGAT
SSPSCANFGL KRTAEDNQEM FSEEAVRTLR RNFYVDDCLK SIKGETKAIS LVSELRALLA
KGGFRLTKWI SNSRKVIESV PTSERPVVVV ADLFILEIYG ACQAPSLDS
//
