ID A0A2B4S901_STYPI Unreviewed; 1534 AA.
AC A0A2B4S901;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Alcohol dehydrogenase class-3 {ECO:0000313|EMBL:PFX27144.1};
GN ORFNames=AWC38_SpisGene8171 {ECO:0000313|EMBL:PFX27144.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX27144.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX27144.1}.
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DR EMBL; LSMT01000110; PFX27144.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4S901; -.
DR EnsemblMetazoa; XM_022932383.1; XP_022788118.1; LOC111328033.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048270; PNMA_C.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF14893; PNMA; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Zinc {ECO:0000256|RuleBase:RU361277};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 403..417
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 1140..1249
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 901..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1534 AA; 171808 MW; 1B13BA7B633EF792 CRC64;
MSETEGKSLS CLAAVAWEPI KPLVIETIEV APPKAKEVRI KILATGVCHT DSYTLGGHDS
EGMFPCVLGH EGGGIVESVG EGVTRVEPGD HVIPLYIPQC GECKFCQSPK TNLCSTIRTT
QGKGVMPEGT SRLSCKGQTL YHFMGTSTFS EYTVVAEISI AKTEDDQPVE DVIEEVKTTF
EVREMTPAER VDFIMSHLEG PAKEEVQMYS KKDRSNPDFL LHILTQAFGE KRSSSQLLKL
FYERKQKESE KLRAYSYSLN ELLKNGTKAD PKAVPDPEKT LRDQFVDNVR DPFVRKELKK
FIRERDPSFL DLREEALCWS EEEERPQRIM PRTPLSQEVS TAAPESSQCH ASSTTTPMDK
VLDALLKQQN SLEELTSSIR DLKQPRTQHP AKEWSGQRSN VVCFKCNRNG HIARNCRTKD
NLAVRGGPPQ ANGLVIPYIG YLELDVEALG VMIPRRGILV VESPASQEAR TNSISVRGFA
KVAGKSQIRV PAGSVSVVRI NGWQGPQTRN TAVLVEPLNG HVPGNLVIIS TLIHVNNGQL
HVRVANVTDE DVWLQPHTRI GVLLEVKDVE DTKNNIDFKR VSINEAMVFV RESTTENKQE
QPSVCPTDLS DVKCTHEQPN KLENLFQKHA SIFTKDENDL GYTETVKHKI PTIDQVPVAQ
PYRRIPPNQF QEAKDHIRKL LDNRIIQESD SAYPPPIVLV RKKDGSLRLC VDYRRLNAKT
IRDQFPLPRI EESIDAIGNA KLFSTMDMAS GFNQRWNSEC QTAFDALKTK LTRAPVLGFA
DYNKPFIVET DASHVGLGAV LSQDQDGQRK VIAYASRRLR PSEKKNPRNY SSMKLELLAL
KWAVTEKFRT YLLGSKFEVF TDNNPLKYLQ TTAKLGALQQ PWAAQLALFD FTINYRSGRS
NANTDALSRQ PHGPVPDETE ESREDELLHI ESILTMETPA PPDLSHAIVT TPIPIEVRRM
AVHEPDLNLS TVNLTSDENK KLLRDNTVIA TTSFPTHTKK ELINMQKADP TIKEFMKFWE
KGTKPTLDER RRLSHQCVTL LRQWNRITRD QGLIYRVVQD PKLGELKQLL LPASLREKVI
TSLHDDTGHQ GLERNLQLIG ERCYWPKMYS DVENWIKNCE RCTLAKMPNP RIQPPMGSLV
ATKPLEILAI DFTVLEPATD GRENVLVMTD VFTKFTCAVP TRDQKATTTA KVLVKEWFFK
YGIPLRVHSD QGRNFESEVI TGLCRLNGIK KTRTAPYHPQ GNAQFHFLMF GWGARLPIDL
LLGEDENVDE NHADCLTEHQ ARLRDAYQRA GEHLKQQAEK RHEQHCDREY DIPIQKGQLV
ADNAPLEKVC LLGCGISTGY GAALNTAKVE PGSTTAIWGL GAVGLAVAMG CKAAGASRII
GIDLNPNKFA IAKKFGCTEF VNPKDHNKSI QQVLIEMTDG GLDYTFECVG NVGTMRAALE
SCHKGWGTSV IVGVAGAGQE ISTRPFQLVT GRTWKGTAFG GWKSCESVPK LVDEYMAGKL
KVDEFITHTL PLDKINEAFD LMHDGKSIRA IINF
//
