ID A0A2B4SCI2_STYPI Unreviewed; 694 AA.
AC A0A2B4SCI2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=NCSTN {ECO:0000313|EMBL:PFX26799.1};
GN ORFNames=AWC38_SpisGene8519 {ECO:0000313|EMBL:PFX26799.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX26799.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX26799.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSMT01000117; PFX26799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4SCI2; -.
DR STRING; 50429.A0A2B4SCI2; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..694
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012563941"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..210
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 694 AA; 77010 MW; 65F97FF77F5CC621 CRC64;
MATELVLWAV SIFLGLLYAA NGDKVAQKIY EPISGVNPCV LLTNATHQIG CTSSMSGHVG
ILHYIKSKAD VDWIIQNGSH APYVPLFRSD LFTLEMVDRL IQKKKINGAL VIAVPSGKYR
YTPQTDSPDY ECPKDNFGIY SESTKYKNCK AVKWNPHGTR MSFKYFDIPM FALNDEAEVD
YLLKCYKKHN KQEHPDYPLC AVELKDFMYA AKDTPTCVRK SNIPNPIGAN FCLPLGDMNV
WGTLYPIKKG KKVVMLATKL DSNSFFHDLV PGVDNDGSGI VVALAAAKAL GALKRNGSLP
ETKYHIMFTF FQGEAWDYIG SSRMVYDMDK NEFPPDPWKV DGEKLTLNTG DIKYFLELNQ
LGLSNGKLWA HSDPLSTKHN ETNKKVSKIV EALKSAGEKH DLEIGEPIDK PLPPSSFQMF
LKKNSSIPGI VLTDHEGSYS NKFYNSHFDD LYQVGGNVSK DNDTVYLITE FTKKLSNISS
AVATALYTLA NDGTAPDFDI KADEALVGHL IFCLFNRSDC PLYREVTDSN KTWTKFQKTS
ASLKPFPRYV SVNTSTNALT ITVEHLLLYF TGYHFPLGKD KDCKTSDGVV AVKVLGQKLQ
GVCVTGSVFL SPALSPAFVL EKYDSIEYST WAESTWNNDL SVQVFLVASP TLEGVTLGAG
LTITLLSFAL VYFINKKADV IFTPADPLSS DLND
//
