ID A0A2B4SCK3_STYPI Unreviewed; 902 AA.
AC A0A2B4SCK3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN Name=Mccc2 {ECO:0000313|EMBL:PFX27106.1};
GN ORFNames=AWC38_SpisGene8204 {ECO:0000313|EMBL:PFX27106.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX27106.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX27106.1}.
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DR EMBL; LSMT01000110; PFX27106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4SCK3; -.
DR STRING; 50429.A0A2B4SCK3; -.
DR EnsemblMetazoa; XM_022932409.1; XP_022788144.1; LOC111328057.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000225706}.
FT DOMAIN 51..308
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 313..559
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 902 AA; 99522 MW; BB7BB85C469DDC80 CRC64;
MRGLKILERS GRQVCQILTV QRCQYHDMSR ACLIGTGAEN FPEFEDNKAK MAAAVQDLER
TISRIKQGGD EKARKRHTSK GKLLPRDRIS CLLDPGSPFL ELSQLAGHKL YGGEEVPAGG
IITGIGRVSG VECMIVANDA TVKGGTYYPI TVKKHLRAQE IARENRLPCV YLVDSGGANL
PRQAEVFPDK LHFGRIFYNQ ATMSSKGIAQ IAVVLGSCTA GGAYVPAMAD ESIIVKQQGT
IFLGGPPLVK AATGEEVSAE ELGGADLHCK TSGVTDYHAV DDFHALQQTR QCIKNLNYQK
TLPVHVPREL PKEPLYPADD LYGIVGDNLK KPFDVKEVIA RIVDGSQFDE FKAMYGDTLV
TGFAQIHGYP VGIIGNNGVL FSESALKGAH FIQLCCQRKI PLLFLQNITG FMVGKDYEAG
GIAKNGAKMV TAVSCAQVPK ITVIIGGSFG AGNYGMCGRA YSPRFLYMWP NARISVMGGE
QAGTVLATIT RDQRAREGKQ LTAEEEKQIK APIISRFEEE GHPYFSSARL WDDGVIDPID
TRTVLGLSLS AALNAPIGSF QRRQKTLNLA TVAVMALVTM NYLRNDRMAS KYSSRSGERN
EKSRALLPCI DENEFLNQST SYVRGSIPKS PWKRRIRVNS EPYVIDNSEV KGSVATVRSG
EDAVDDATKA GKFSCNQKKL ARRATLPVKY VSPNKDSLLS NAKTTRSRNA TVKVKSKAPS
PDVLDLSNED VVHELTRRLY VSLGVSDKTP CQQLEIDQTD SKVEASSKQT RNKNACAMTE
KSSERLPYVS KITSNLEVFY SKPASWKTLI NSRHLCPKTR TKRCSAFQAK ENKPVKEKPM
LQSNEHQLTW PLKRSFDFTG QSTSVRRERG LSEPFFAFIS HSHSRDMFRR SYDSHKSVTF
AE
//
