ID A0A2B4SD14_STYPI Unreviewed; 1319 AA.
AC A0A2B4SD14;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:PFX27266.1};
GN Name=Rad50 {ECO:0000313|EMBL:PFX27266.1};
GN ORFNames=AWC38_SpisGene8052 {ECO:0000313|EMBL:PFX27266.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX27266.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX27266.1}.
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DR EMBL; LSMT01000107; PFX27266.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4SD14; -.
DR EnsemblMetazoa; XM_022932143.1; XP_022787878.1; LOC111327850.
DR EnsemblMetazoa; XM_022932144.1; XP_022787879.1; LOC111327850.
DR EnsemblMetazoa; XM_022932145.1; XP_022787880.1; LOC111327850.
DR OrthoDB; 5477220at2759; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 637..738
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT REGION 480..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..283
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 751..819
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 843..943
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 685
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 688
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1319 AA; 152378 MW; B9E93447FE3FB8A2 CRC64;
MSSLEKMRIQ GIRSYSHMEP SVIEFQKPLT LIVGPNGAGK TSVIECLNYM ATGDMPPGGK
QSLFVHDPKV AGEQEVRGQI KLKFKDVTGS PIVVTRTLVS EQRGKKVVTR TMEGNVLREV
HGERRSLSSK CADINREMIS FLGVSKAVLD NVIFCHQEES NWPLSEGKVL KQKFDEIFAA
TRYIKALEAI RKFQKEQVQT VKEYSIELAH LKANKDKADQ IEVEMNESQG KIAATKDTVR
ELNTKLEPVE LRLTELAVIA DDVFELEKKV ESLSTEKKQL SKVEIDLQDK ITNPFDGSVE
ELHKIFSEFQ SRVLEKEETL RENEGKLHKL GKDQQVLSDK RNKLFLDHGK LEQESKRHEA
NLMDRNQTIV KIAEDYGLKG YDKGPFSEDR VDQFIGEMKK KFQDVVENAK RQKQVFDESL
NKAQAKLDDV KKSQAQCEET IRLKTKLMRE NQQKLRQIGQ ELSNVDASAN RLKSLEEELQ
RGERDLQGAQ ESGNVDELSK DIDKLQTEKR KVDNELRQLR EEQQAMHMQS TTQAKLDMLS
KEKNDKEDAI QKIMDRHEED LKSTFGALGI SESLYLRLQE HLRTKERELK ESRNNLQKLN
QQLSATETRK RMILENLKEK EKEAERHKRQ ISEVCGENDY NTTREAIKDK IANLQDERGL
IGSLEKIYSK YVSKLDSEDV HSSGCPLCHR TFESDRQITA LVSELRSKIR TLPERRVSME
RQLDHEQQRY DRVIELAPAK ETLEKLENNQ IPVVKSELEE MESEIQRIKD EITELEDVQS
VTESEAQSAR DMEPDIRMLD KYKSELKEMD KNISLLQSKL RGVAPGRTMQ SVSNELTDRQ
DRSDTLNNHI DRKRTQLSQL QRQLSDLKTN VHELKSQKLR LKAQLQTRTH LEQQKAELTA
NNSAFAREIE EAQADIAPIA EKLEELQEEK QRVVGEKEAS DDENRKKLQE IRTRGDKVRE
KTAEIKRFVS DGGPMALQEN EARLQEVEGR AEKLKSEKDA VSGEIDKLKN DISKQQIRAR
ELKDNIQLKS TQVEIQNIEK KMADVYKELR KFGDHQDLVS ERQELQQRSD NLRKEKAHHE
GRLTGYEDDL GRCQKELRSD MYKNAEEKHR QQVIAMKTTE MANDDLGKYY KALDRAIMRY
HGMKMAEINK IIKEYWINTY KGNDIDTIEI RADEEEGSGA IKARRTYNYR VVMVKGDTAL
DMRGRCSAGQ KVLASLIIRL ALAETFCLNC GILTLDEPTT NLDEDNIESL ANQLASVIRT
RHLQRNFQLV VITHDEEFVE NLGRSDFVDY YFRIYKDENG FSKIVKQSVA ALHREESFQ
//
