ID A0A2B4SG89_STYPI Unreviewed; 6417 AA.
AC A0A2B4SG89;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Fibrocystin-L {ECO:0000313|EMBL:PFX28366.1};
GN Name=PKHD1L1 {ECO:0000313|EMBL:PFX28366.1};
GN ORFNames=AWC38_SpisGene6898 {ECO:0000313|EMBL:PFX28366.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX28366.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX28366.1}.
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DR EMBL; LSMT01000084; PFX28366.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4SG89; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR CDD; cd00102; IPT; 2.
DR CDD; cd00603; IPT_PCSR; 11.
DR Gene3D; 2.60.120.1560; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR018871; GLEYA_adhesin_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF00028; Cadherin; 7.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF10528; GLEYA; 1.
DR Pfam; PF01833; TIG; 13.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 13.
DR SMART; SM00710; PbH1; 10.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 13.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 7.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT TRANSMEM 5979..6001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..404
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2108..2227
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 2936..3074
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 4400..4506
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4507..4615
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4617..4725
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4726..4834
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4835..4941
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 4942..5051
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 5053..5177
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 6371..6409
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 3886..3908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6052..6101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6144..6212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6228..6265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6144..6207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6230..6252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6417 AA; 700428 MW; 9320C7B6AC3B943C CRC64;
MVSDSYHAIS GRVTQITPTT GSLLGATRLT IHGEGFAQNQ FNEFEKELGN NVTLVSVSRA
HVVPCDVISY YTTPYRIVCQ TRPSPSGEDS YNIRVLVDGK WLHNTGVNVY CRGECLFKYT
ETKTPTITSI TPKYGLPGSL LEIRGRMFTD QVIETEDFDP ELSSIERIFA GADLCEAKDP
ETDQLYGIKI EDQKTKTGYI KCKPVSPLID VVEVSPAVGS TAGGTVLTIK GKGFDVRAKK
VSVAVSGVPC EIKSIETDII KCQISEAPLV DNDEFYSGNG GLRNTASEVL PEASSTSFSD
RLRGFFIPPS DNNYTFYIQA DDLAELYLSG NESASAKTKI ASCPKASASW SDFPEQKSMM
VSLRKGQYYY LETVHVQGGG KSHLMVGVKM QNTRHVNSQT GSAVNEKQQI LLNSVKRPEI
QVINITSWDD GKLFEVQIVN VIRSCKQTKG NNTLYEEVFF LSYNGDNTVP LPLNSMTAKM
LQCAINNLTR IRKQGEVDVT ELVANNKSTS YRVTFLFKDP QNTNMLRSNV TWVNITRAQK
GVPGNYFWKL SLAGRISGNM HINATENDVK RQLLDMIGWH CSYQTPPDRA YYYNGFETPS
LGPEYGERVL KQTANCGRFS LKNPKYIFFG GQTKDKWGRI LQGYDVARYE QDDSSFLKPS
LAGTFIVTVV QIGKMKDFID FRISYTDKFG ADQQSWRKYS IVTIPDGKWH QLCINVHDRV
LHDVNVKADL RYKIYVEVIS VSRDLKADIS FDDVFIWSDP VMVQRLLHAS EPGGNIIESV
DVQSLGPSVW SVSMTPSCCG TGFELLQVAD AILVGGNATS DQAVFRPTNS TEDASISVSR
FQAATPPIGG TFDIFLENYN VKGIPANISA EDLKSTLESN FDIGKVSVKG FGTCSSFSWT
IEWATTGGDQ PAIRVDGNGL TGNNVSVKAV TLDDGGLFLR PIPGDMLRVA ERKPQVTVMF
DNIPSSCFNR NCSFTFSSSI TPTLSTISPQ RGTKGTLITL TGSGFSTSAQ EVNVTIGEAL
CHVISIGETT LKCTAGQSSG GSHDVVVKVG NKGFAKHVSG QINFSYEVYV SGITPNRGSI
GGGTYVVITG DGFGLMPGNS SVTISGSVCN ILSIKLTEIT CVTTPHDVSN ASVTVATGDK
IGTLSNSFWY DSGFTPLISS MSSLEGSVSG GEDILIKGSG FGVQKGTIKI GSRPCEVTLY
SDLLIKCTTP ANAPGTYDVL ICVDGKGCAV NATMGFRPPK FKYVLEVTGV SPSQGSVFGG
TLLTVAGRGF SDNSSAVSVI IGDVPCNVLS SRNTEILCKT DASSTTHKVD NTGIHPEYGI
GYAWNPQTIA INAGDSIKWQ WTSPELSGLS YGVQQTRDAS SALYDGKGFK SSRSESGHFT
KQFKLPGTYF YSSGAVDPYG AIVMKGKIVV KEIKSKSVDV RVQVGAILAP YNSTSPKFPD
AGSSDCQLGV TNAIPKCISS DPLPSNLSSY GFTFGKCSTP EVTSIIPNSG TSSTLVTLKG
KGFGLINCQN EVKIGSSDCT VQSSAEDKIT CLVTTRNQLS SGSPHSVYLR VKNRGFALIK
VQHEQNASFT LQPRIHTVSP QAGSIMGGSI LTITGDGFSP VPEVQVGGVP CQILASSYTQ
LKCQTAAGKA SQVLPVVVKV NGMESNCGSS CTFTYSDAKT PRIDSVTPSV FVGDENTIHI
YGSGLPSKTS DLEIKIGNSP CIVTSLSQYS ASCRVGPVVA GKHNLKIHHG PQGLAMFEAG
ASDMINSLAV VSSITPTEGS IMGGTELSIK GSGFDPTAGH TNVRIGANYC SVVRVTSSEV
VCRTSAHDPG SYEVIVTANS ITFPRLRYAY RTFITPYVKS VSPARGKGGK TVSIYGSGFS
SNTADVQLTV ANVSCSVETS SETHVTCILG NSPAGIYNIN LHVKSKGLAA YPSLKPVKFF
YEISLDSIWP NDSGLGGGRI VSIKGHGFDS STIVRICDNI CVMVNSSLNE IYCEVPPYTR
QADRPDINCS VSVVGDSDVS SSKSGLFAYR ESLTSRITSV TPSLGGTGGG AQLTIKGNGF
SPNKDGNKVF IAGIPCEMTY FSKTEIRCTT GPRKGTIETQ VRVEVDDKGI ATQDRADFQY
IDVWSSPYTW GYKNPPEKGD GVVIPKGQTM LLDVDTPVFS FLVIRGELIF DEKDVTLNSE
KILVTDGGKL QVGTENTPFE HKAKIILHGH MHNKRLPIFG TKVLAVREGT LDLHGKAVPI
TWTNLAKTAV PGDTQLILKH SVTWEIGDKI VLASTSRSQR ENEEFNITSL SPDGRTLGIT
PPVKYNHISI VQTIAGRTIE TRAEVGLLTR NVIVEGSEND EWTENIPECP EGFDPGLFAV
QTCYQGRYGK SMGSEQFGSQ IMINARMQSE GLVTGRISYV EVRKAGQAFG LGRYPIHFHL
SGNVSGSYVR GCSIHHTFNR AVTIHGVTGL LVEHNVAYHV MGHAFFIEDG IETGNAIQYN
LGVFVQTSST LLITDVTPAT FWVTNPNNTV RHNAAAGGSH HGFWYNLPKH PGGPSFTTSV
CPKKSPLGEF QNNTAHSFGR YGLWIFKEYF PMRGGRCDSS ISEPAKFFTF LAYNNLKGFE
VTSGGAIQTI NFTVIDNSEA GIEFTNLNAP WGDNGPLVKD SLVVGHSAVS EGPGACTLGG
IVTPQSSQLT VSGTTFVNFD SPSCAALRAC SFCEARQGGF TTRFEKIGFV GAPNKAAFKW
EHEAVFEDLD GTLTGLSGGG SILPSNPNLP PKRCFQSPSA SVSGISGSVC DSTMRFRRMA
WNNPFPSSLL YRDALLTNEH GTSHIPWRFM RLTHDQGWMA TIILGQNYNF SFDNALQLTN
ISYSAVFYEF GAQDYVWMTH PMKQLPDMIS TTGRYINMSS GLPSPENSSN GDWFYNNETK
RLTYIVSGKG RLEVGLTDLD IKMQVYRCFF KNCVKPIPPP PPEKRPLEYL RWSDPEAWYG
TIPGHGGYNK QLPQDGEDVI IQKHWWMVAD TEIPDMRKLF IYGTLELEPY MDFVLNATYI
VIGEEGNLII GWEDQPMTGN VLINLNGNWD TPDIPIQGGP NIGSKAIEEV DWNPGEKIVI
APTSYEPYDT EIHTIVYVFP DRKTLQLNNT LKYRHLAESY RTGTWNYSLA AEVGLLTRNI
VIKGADDAGH VLEKQSFGSR VLIGSFNGMV SSNRRFRMEN VEFHHCGQEG WSDYFDPRYC
LAFLDVGNLK SSYIRGNSFH DGFNTAIGVF GTHELIVVDN VIHHTVGSSV RVWGTNNKVL
RNLAVLSVSP ATYKGRHEVN NKLWHASFDI SKASSIVLRD NAAAGSERIG FHIRGETCYG
DSPDGGWKGI LLNVWRPPAL SHVTANKFVH LDRVLLVGTS PSFQCASDLV APRNSHITDQ
VRAPRYKGGG NTAFMLSTFA SGPGLAPEKA WHGINAYPAI PGVVRLTDVG FAYFGTKCGH
DSVVFTTNPK SPDAFHPVEI RGISLHNVDY DKLIYIPPSN IAWINPSDCI DMDCDGAKHV
LLKDLDGTLT GTSGGSVISK AEYEWNGDSR RGLGDYRMPR ALLTSPDGSQ LNASVVAPHH
GIVRGTRAQS FCSWNAAWNG YKCSKLDYHM FIIESLDADT ELRRLSPVAL SSNGYTDLLN
GPMDHGCCFG YACMERISTF FSIVATQQSY TIYFTGTNPQ SLRLMLLNAN SSQALRVAIR
YTTSQRLDVY RTGAFIFPTN AKLDEKNFSY KKKDPKLPDG QFEPTLNSIS GANYYDRESQ
LLYVFVKGNV PLDIRTAPVV QVKLGSRPVH FNDFFEKNLI QNLASLLNID ESRIRVVEIV
NAAGKNRRRR RASDDEVMTV TIEIGDPPER HISYTPEETF SPGNSTFTSP PFVTATTTAS
PSKSPIGQYI GLQSIASKIV EAAQTGHMAS SLDLDILSIK VTDPEPPRKL PEGWKRATPE
DAGPKNGTWR FDQVEMMKEG NKSSLAHDYL IPLRLVIVQQ PRGANETVPF QIQPKLVMVD
KLNRTVTMLG HSDREQWYVT ASIKNGTGDP GALLGGNTTV PCYDGWANFT NLNISHNGTD
YVLEYRVSLP SEANFTSAST PFEVKERVLY FALVRHPGDS NETVPFGQQP LVEVRDAATG
ELVTNTGWKG RKWICLASLL NSHDYKGNLN GSSSVEFSGG VASFRDLAID HKDNNYILII
KAFTVPSSRY QFSTNTTPFN VKERVLDLVI TQQPGDCNDT VPCGHQPVLE IRDTATNMLV
GNLGWRRRKW TILASMEEGA GNQVLLGQRK FQIPVSGRIE FSNFSFYDAA TDYRMKFNVS
VSPYSQAYSG MLAMSDSFDV KPREFYLEIV SQVARANQSV PFGTQPVVEV RDLGTGRKAA
PLKTPWWITV SLYANPQPGG SFLNGTFNIS VVEERAVFND LLVTLYGLGY VLKFESSYGH
VVLSAAFEVH YVNDYSPVFT PGNRTVHIDE GTVIGSYVMA IHATDNDIGS QGDVYYTLHA
GNIDNSFHIN RTSGVITTAR KLDREKNAVY NLNVKAYDGA VEEKVRYSLN LVVVHIGDLN
DNAPWFTKNG YASRVNETAN LNDVVLGVDA MDRDAGANAK LTFSITSGNV DGYFDIKADT
GDILVKRSLD LEGSAPPSLN YSLAVHVTDL GSPTLSNSTV VVINIAPANE FSPQLTHEQS
ASITLKENYD PGNGLVLFDV NATDKDFGVQ GMVHYFIYSG NSDGKFAIDR SSGVVTLTSS
LDYETSPLYR LIIRASDSDP TGGARYTDFD LQVHVEDVND NHPLFSNNYT LIQVPETLSS
GEKATSFLAT DLDSGENGRV SYVITSGNSD GYFSLNAYTG DLTLQKSLDL ESAQAPYPNF
TLLVEAKDYG NPQLSNNATY VLKVKEVNEF TPEFTHPGRS LQIPEDTAVG TLLCQVTATD
KDFGLDGLIT YQIINGNEDR RFRIESSGKI FIHAPLDRET TSKYQLEIKA SDWPVQIADQ
RSSVMIVNVS LRDINDNRPV FSKGSYYVAV KETVKVGSDV ITVQASDTDA GSNGQVVYKI
KSGNTPGFFE IDSNTGIIKV RKSLDLEAQQ HVADLLYTLT VKALDKGKVP QTNEVLVSLE
IVSVNEFAPQ LQHSASIYVK LPEDTAVGSI VGDINGTDKD FGMDGQLSYS IVAGNKDNNF
DINSKTGVII VNKDLDYETV VRYTLVVRVS DNAPSAQRLS TIAKVTVRLT NVNDSGGVDV
LIEDVINKIS PPGDPAVAVG VAISSPISVL LLFENGNREK LSDDDSRLTF DDKSESGGLF
SVVSASGKRV IEANHQGLLG HGVLIVRVHN VYNVRVKINV VGFSSLQLSA VPYPTTKRSN
VTLKSLKRIG NRHGNVQSAA LVLNLILTDN STYNVTKMIS ASFSVVSNDV GVKVLVGPSP
RNVLFVERIS ISGNISLIGK FSGRASSQLR LEVSTEVITV NEIVAVEITG LRNQTLVGPA
FATQAQVQVD FAMNDSSMFR VQNFSTFPGL VAFKSSQEDV ALVDNTTGVV TLLSDYYDLV
TVTVTPLQGL AEPHITQFYC NTVPPVGGVD IGQKYGPAIP ALKANQQITI PVRVNPGKAK
LLAFDVKISF DESQIHFVDL KGSRAYSYTY GQLHIADLTN PDNATSHVAD LVYDSLVNGV
PTIQATVNML MDQNLGYIGD FSPTLTPCQS SQLGDVNADC VFDIKDPAFA LAYSLAVENN
FNSEFGQMLL KRTTTKMLQV MDFNLNGVLE RNDAYLLARA NMDMVRFLNL FHMTVPDHQN
ASTNCEFELI AELSTRDGTK EKNADTQLYF ELAGGSDILN AQLESTSFNA GELVATYNHE
HELFGGIVKA EHRGESFLVV AKQFQVEMED LGVSMIQVTK GGQWPEPVVT PLFMFSRYQM
FPAPIRVQLA PNAALVVSSG HSPQITVNIS ESSSTCLDPP VMKNVMFVFQ NDFSKVEGNK
DIFVKTIIKD LTSRFSRAKI DNVTLARGSI LVYFDITAQR SQIDKTLVAL WDMIKSGYIL
RVNNTEYQAQ MVMRVDGRDY HGNDKVLHAE EDRSTFPTAA VITVCGVVVL GVITGVAFFF
CRKRVRRAKG KHSWKSASKI NMIDSNSASQ RVQKMGDTEM ILFSGLTNDC FESSDNETPP
SSRPSSRNTS AKTGNFSKRK VRKVNSASSQ ASFEAWSENT SPALVRRTPR LPLSSLTIDA
NIRDSSILGR QTVIQKSDSQ ILVQENSSTE GSPINLSPQT PKRGLSPQKL RLQAQNGSSF
GSDSSDEELT RNGTPSSANS GTPTRKSLKD QSSRHFIFEK AVLYKRLMAQ ESPQTRSRDS
SRPSSGHSTP KMNVTLLPPG YAGNSNDGND ITVEEESYTV RLPVNVLNTV AEGEGRKPFT
KIGFVEFPSD ATLADTREIL KKEFLETLLG RVFLFQDAMM ADVEPSSEAT TKSMYNLSVI
IRFANTQEAA LLFCPCGAAA HFHCSACHRR GYCSRDCQAM DWHRHKIACE DEQVSSV
//
