ID A0A2B4SHP3_STYPI Unreviewed; 1330 AA.
AC A0A2B4SHP3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Histone-lysine N-methyltransferase SETD2 {ECO:0000313|EMBL:PFX28906.1};
GN Name=Setd2 {ECO:0000313|EMBL:PFX28906.1};
GN ORFNames=AWC38_SpisGene6343 {ECO:0000313|EMBL:PFX28906.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX28906.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX28906.1}.
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DR EMBL; LSMT01000074; PFX28906.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4SHP3; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR000885; Fib_collagen_C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF01410; COLFI; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PFX28906.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PFX28906.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1075..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..112
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 114..231
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 238..254
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1025..1058
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1261..1330
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..907
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 148758 MW; DBEFA13DABF46687 CRC64;
MSTEERSDNS GHTDDSGSDS EEDVSGEHVI SSTEECQPPY YEHIEENEYL FDRKKKVNKE
VRRMQCDCTL DSDDPSSSGC GEDCLNRLLM IECNSRCACG EMCSNKRFQQ GCKVKVEVFK
TEKKGWGLRT LEDLESNQFV MEYCGEVMNY KDFQERAERY DRENRRHYYF MTLRADELID
ATYKGNLSRF INHSCDSNCE TQKWTVHGLL RIGFFTQRPI PAGAELTFDY KLQRYGKVAQ
ICHCEAPNCR GFIGGDKQTP LKNTVERIAT PPITSSPRRR RKKQTRNLTN EFDDMTLEDE
VEKLLGEHRG LVHSDQALKL SRLMVQAETM EQRIMLLKIL QHTTDQSCLK GFLRYQGLSL
LWSWMVDGGG KKTKLQLELL ETLKCLPIAT KNQLEDSKVI KVVRKWASSF CPTAEAGSSS
GQESHGNSPA DSECTAGTED NDEESQQLSK SIDGDKKAIG IPVSLFERQS SNKDQSDDES
LDAEVASFIV DKTLDSRAMK NKLLSENFEK SPDDLSEDDL KFEDERLPEI GIGLMANELL
KTWSLLKEVY RIPKKTATPA KQDRVTELLV AASPAGSGDG DHARTPIENI GSPGKLDAIM
KSLQDSPKPL YPSESRTPPV SQGFSTFSED TEMLQDSSSA TPPSKTGDFS ALEFGEDVDT
QGDSTPDKGE GAQPSSQVSD SVEVPHKQDS KSQNTMQTFG YQQRMSVGVE HGLGAYKHKP
SKKKKKKWNQ LHNVFQQKGR NPQGSVDKNG GNFNMNPQTN LRPQQAAATQ WRGQSQNPPA
NFQVGNQFFC SSGPTVGQDQ GPRPQNIVSG NFLGNFSQQP PPLPNFNVPP PNMSPMEFFR
KVPPPNLRQQ THPMIPQQLQ PSPLIAPPQP VPPPPLQNNQ SQFFPPSQPT PPYSRLPPPP
PFQANVTTPP PTQFSHSNPN PIQQQFPQSM QAGFPPQQNQ FQFNTPPPNL GITAAQQGNS
VGIVTGSLQR QSGPMESVSH PEVGSLSVQT GAVTTSMSET FESREGFPSD SEPCTPSPVK
HKPPDHFPPH WKSATDSQGK VYYYQALTRR RQYQKTVMQQ ENLGAPPGKD KTANFSIPVV
GLTQFAIITI NIILGILFVR ANTDFCGSVF ETRIDHALVG NVMHTTVVVY EFECQIKCMG
NNSWRGSSAR SSFSPDDDYD DDDYSRPSLA KYSEPSLAQY SRPPWARPFL DTNKVAYKPQ
QTSNSLFPCP KERDEPDRQK SGLVYKINCT QCNFKYYGQT ERSSKTRIVE HKKAVAAIKG
LYYNQPGHSC KDIRDSGFFK KDGEYWIDPE KNGKPLKVYC DMTTDGGGWL LVSNVVVDDP
SSRDLWIESS
//
