ID A0A2B4SKA9_STYPI Unreviewed; 908 AA.
AC A0A2B4SKA9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO4 {ECO:0000313|EMBL:PFX29539.1};
GN ORFNames=AWC38_SpisGene5729 {ECO:0000313|EMBL:PFX29539.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX29539.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX29539.1}.
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DR EMBL; LSMT01000064; PFX29539.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4SKA9; -.
DR EnsemblMetazoa; XM_022928411.1; XP_022784146.1; LOC111324777.
DR OrthoDB; 2909033at2759; -.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF84; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 301..328
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 381..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 461..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 505..528
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 551..572
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 671..697
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 721..745
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 832..857
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 54..286
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 290..871
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 104496 MW; 6C712EE67A6F0B53 CRC64;
MLSRLLRKRK DPTMDRGSYS ELSQTDGSNQ GVELEVNISP LAESSADKSS TRDRDHGKRT
DYVLVYETCK EKDGKDEESK KEAEALARSR RSFERRLQKK GLVLQHEIVI AEKEPEVQRH
FVLIHAPWEL LASRAEDMKL KVPLQPNDVE FTSWPQSFCG RDRLEKMANW NPLIIHDATV
RERADNFMGR FDKEHLTTYM NHEDKEIFFP TVDRMHVVYQ ILQNTRFAQD PQCLGLKRLV
LDGAYIAHYP LHEGTENLCN EDSPVNDRQR LKRDWARLGR CFKFQPYDAI KDYFGHEIGL
YFAWLGFYSA MLVPLAIVAL IVFLYGIITT GSHAPVQDVC DEKNDGVWYM CPLCDRQCSY
WNLAPTTCLY TYVTNVFDND ATVILALAAS IWATLFLEFW KRREASLASE WHTSDFEEEE
EPLRPEYVKS LTEEERNPFK PDPETGKIVY RASKMKQYRR YATVFSVIAF MICLVIAAII
GVVVFRAATF AILSSNPDRV VQKRARILTT GFAACINLVA ITLLKYVYNK LAVWLTNWEN
PATRSAYEDS FIWKMALFQF VNTFASIIYI AFFKSQSIVG SPGRYRRVLG KYRLDGCSEQ
GCFLELCIQI AIIMVGQQII GNVIEVGIPS FQLWLKRRKA ADSGDRPQYV KDHELSELED
HYLFWDYLEI VLQYGFVTMF VAAFPLAPIF ALINAVLEIR VDAINFVCYH RRPRAVRVED
IGAWHGVLAA VTKIAVLMNA FILAFTSEFI PKLVYKYRFA PDRNSPGGGT LKGYINNSLA
YIDLKTLYTW EPGTEPIEPT ANVNYTRDYC RYSGYFDNTY PYNRSKEYWN VVAARLAFVV
VFQFLVYSIT SLIAWAVPDV PENLKFKQER EKQVVKEKLG APSDDDDSGE DEDDAVKTND
DVTLVFGI
//
