ID A0A2B4SMC0_STYPI Unreviewed; 1235 AA.
AC A0A2B4SMC0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=5' exonuclease Apollo {ECO:0000256|ARBA:ARBA00039555};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE AltName: Full=DNA cross-link repair 1B protein {ECO:0000256|ARBA:ARBA00041693};
DE AltName: Full=SNM1 homolog B {ECO:0000256|ARBA:ARBA00042738};
GN Name=dclre1b {ECO:0000313|EMBL:PFX29728.1};
GN ORFNames=AWC38_SpisGene5471 {ECO:0000313|EMBL:PFX29728.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX29728.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX29728.1}.
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DR EMBL; LSMT01000061; PFX29728.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B4SMC0; -.
DR STRING; 50429.A0A2B4SMC0; -.
DR EnsemblMetazoa; XM_022928091.1; XP_022783826.1; LOC111324514.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF8; 5' EXONUCLEASE APOLLO; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Exonuclease {ECO:0000313|EMBL:PFX29728.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000313|EMBL:PFX29728.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 272..306
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 596..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1235 AA; 140039 MW; 2C56C320E5AB4FD1 CRC64;
MNGAVIPDTP IAVDFWRLRQ CAHSSIFFLS HMHADHTVGL TSSWNTHPIY CSELTKKLVT
AKIGVNSELV IGLPLDEPFV INLDEQGQET MSVTLIDANH CPGSVMFIFE GYFGKILYTG
DFRHCERIAT HSAFKRRVFD VLYLDNTYCD PNCIFPSRTE ATINILEIIR RHSEYKIVMG
LPNLGREMLL HTIAKAFRTW IGVDPLRRET LELIEMPNVF TSEIDKVRIR VVKNIEITRK
NVQAWNSVEP TIAIIPTCLY VGGINPFANF DNVFVVPYSD HSSFEELQKF VQIVKPRRII
PIVHKCRLSP GETINARVNM NVFQSLMDYS LPQKYRIPHS VACFMSSTAQ QPRKKKKIKA
TVQLCRRKAA KSKKPQGVVF SPSPEKKLVI EGNCELDTGI EDCSLSKEIT GVQIRPVTSE
GKSCVEEGKM SDKQLLSIAE EITEDENKVA SSMYNKSSLS DSDEIERSNK SILNCEDTND
KEQMITEDEM NAIASPTIKC GKATSEPEGL SEMDTDNFSI DIIIPADEVN LVASSAVEAQ
MAGSKSEGNQ HFSHVSSGEG FQGESMVQET CGNKNSFVGL LSGTKDVAGS QMKEEPMVHH
SVEDRRVKHV TSASAKKTKV SPDEHLSSPK RSISNYKIKR RDMNDDVITS AENTPLKNLS
LKRKFQDIDA NSCENVVSEV DSRRSDMKFN IYTGSTCDFA RKSERELKYI GRSKFLDHNP
APRSNSTSEI LTDLWILKLQ QFAVSSIFWV RILEFACEEV WIVDLNDRQK CVVSGVYLAS
DLVSDLYLIS SMITSVKCFH TLKERFGLPF TGTLLEVRTE ASKFLKRKEE EYASLGHDKH
QVNFMDKAIE AHIQAITLVD RERLEFLADS HSKRIHSAQL KGILLTDQEE ASLLMGREEF
RYFLEPKLKE VKMVPSWNAS RVQATVLILT PLEIITPLSV RNSKTFRIQA VSKLYDAFSV
HSVPKKGQSP PPRTLPEATE KVKECKQILA EYEKSVPSVP GCSKMIQNGP RGTVSAVTVR
SVDMLHWELG RMRSLFSSLS FDATNLPGRI TRDVEHLPST SHIKHPLLSK KEYCRDLGNT
IKESTKRLSS STVYYYTGEK SSWYPVPEHE IPLATRRTIP QLPVAKLLEK AVEEMRNYAL
TYTYRAAVRQ RTNRQETTMA RYGTMPELIY QRQLQIPEDR VDLALSEGSE SSEVNENEEE
VETGESDREN VEEVPRVRLK YRRRRGIRRW KFKHS
//
