ID   A0A2B4SME1_STYPI        Unreviewed;       482 AA.
AC   A0A2B4SME1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Acid-sensing ion channel 2 {ECO:0000313|EMBL:PFX31864.1};
GN   Name=Asic2 {ECO:0000313|EMBL:PFX31864.1};
GN   ORFNames=AWC38_SpisGene3270 {ECO:0000313|EMBL:PFX31864.1};
OS   Stylophora pistillata (Smooth cauliflower coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Pocilloporidae; Stylophora.
OX   NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX31864.1, ECO:0000313|Proteomes:UP000225706};
RN   [1] {ECO:0000313|Proteomes:UP000225706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA   Tambutte S., Allemand D., Aranda M.;
RT   "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT   digitifera provides evidence for extensive differences between species of
RT   corals.";
RL   bioRxiv 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFX31864.1}.
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DR   EMBL; LSMT01000030; PFX31864.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B4SME1; -.
DR   EnsemblMetazoa; XM_022924484.1; XP_022780219.1; LOC111321568.
DR   OrthoDB; 3414706at2759; -.
DR   Proteomes; UP000225706; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        31..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   482 AA;  54686 MW;  A3BA941BB92E01ED CRC64;
     MVAAKWRKFV SDTTVHGLRY VFESPSRFRR LIWLLLLLGA IAIDIYLLRE SVQKYFSKPF
     NTEFTEVVPE NGEVSFPAVT ICNLNRFVKR KINMFENDED FHKMGLNLSA CEVVNKVNKS
     MSCGQGLLCA FEQFGWALAE NCNENIRQQI ITALNRTKEP IFNPEEFIGN FGHDFAEMFL
     HYCRFPVSQN CTSADFHQTL TKNGRCFTFN SGKNGTKVRG TKRAGVSGGL SVILDAQAYE
     NTVSEFSRGL RVVVHDPGAI VNLDKGFNVF PGSHTLARIN AIKRERLPYP YKSDCTRRVL
     PKIPRYSRDG CFIQCKANVT LKRCGCREIG VQVPSNSPVC TFQHEFCVEQ SEESHNPFNC
     SCDIPCEETE YLSQVSYSQF PDDGASKVLK YMHAYNKSIK HQRENLVFLQ VGFQRHGYTL
     MKESPSYKIG SLMGDIGGNM GLFLGCSLLT LFEFVDLAWN ILEYQANKKK SVSQEKMGNE
     AV
//