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Database: UniProt
Entry: A0A2B4SPL5_STYPI
LinkDB: A0A2B4SPL5_STYPI
Original site: A0A2B4SPL5_STYPI 
ID   A0A2B4SPL5_STYPI        Unreviewed;       398 AA.
AC   A0A2B4SPL5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 2 {ECO:0000313|EMBL:PFX31851.1};
GN   Name=Kcnj6 {ECO:0000313|EMBL:PFX31851.1};
GN   ORFNames=AWC38_SpisGene3319 {ECO:0000313|EMBL:PFX31851.1};
OS   Stylophora pistillata (Smooth cauliflower coral).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Pocilloporidae; Stylophora.
OX   NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX31851.1, ECO:0000313|Proteomes:UP000225706};
RN   [1] {ECO:0000313|Proteomes:UP000225706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D.,
RA   Flot J.-F., Tambutte S., Allemand D., Aranda M.;
RT   "Comparative analysis of the genomes of Stylophora pistillata and
RT   Acropora digitifera provides evidence for extensive differences
RT   between species of corals.";
RL   bioRxivorg 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PFX31851.1}.
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DR   EMBL; LSMT01000030; PFX31851.1; -; Genomic_DNA.
DR   Proteomes; UP000225706; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000225706};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:PFX31851.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    109    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    200       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       74    205       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      212    393       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        191    191       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   398 AA;  45272 MW;  AF8EAEAFC0DD1504 CRC64;
     MDSAISKERL VDEDFQSDQL DEETEPTTAV NAGTSFVHRG SIGVSISSSL IGSASIRGET
     QSKNSLDSGK RRLVNKSGEL KVLAKNVPRK TRLYLADIFT TMIDLRWKWV LLIFVASYII
     SWVVFGFSWW LIAYVRGSTV CVWKVSSFTA AYLFSVETQE TIGYGQKAIT TKCPEAVILL
     QLQSLVGLII DAFMLGLTFA KLSRPRERGK TVMFSEYAVI APRDGKMCLM LRIGDVRKSQ
     IVDASVRMQL FRTHTTAEGK EIPFYQENLK VCYDWRDPDN DFRNKLFLIL PLVVIHIIDQ
     NSPFYEFTPQ MLQRSDFEIV VVLDGVVEAT GLNTQPKSSY LSSEILWGYD FCNTLEKSQF
     SAKGFYHADF SRLNDVHVVE TPRCSPREYY RQKQPEDA
//
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