ID A0A2B4SQL1_STYPI Unreviewed; 2029 AA.
AC A0A2B4SQL1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=holocytochrome-c synthase {ECO:0000256|ARBA:ARBA00012218};
DE EC=4.4.1.17 {ECO:0000256|ARBA:ARBA00012218};
GN Name=NALCN {ECO:0000313|EMBL:PFX30812.1};
GN ORFNames=AWC38_SpisGene4406 {ECO:0000313|EMBL:PFX30812.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX30812.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
CC -!- SIMILARITY: Belongs to the cytochrome c-type heme lyase family.
CC {ECO:0000256|ARBA:ARBA00007255}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX30812.1}.
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DR EMBL; LSMT01000045; PFX30812.1; -; Genomic_DNA.
DR STRING; 50429.A0A2B4SQL1; -.
DR EnsemblMetazoa; XM_022926388.1; XP_022782123.1; LOC111323099.
DR EnsemblMetazoa; XM_022926430.1; XP_022782165.1; LOC111323133.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004408; F:holocytochrome-c synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR000511; Holocyt_c/c1_synthase.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF01265; Cyto_heme_lyase; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00821; CYTO_HEME_LYASE_1; 1.
DR PROSITE; PS00822; CYTO_HEME_LYASE_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1116..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1259..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1318..1338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1359..1381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1451..1473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..342
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 396..610
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 905..1177
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1225..1482
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 754..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1820..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1643..1671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 230325 MW; 7B16C19E4ADDC66B CRC64;
MEARGQSVVI ESDQHSSSQT LWPPRQALYA ESVGTDDEEN EDELSRTWWV KTRWFQRLVQ
VCAVASLTST AMNSPETFKD SVSLQYITLV LDIVVAAVFI TEMIAQINMW GLWRKQKAYF
KKPQCIFNAS MVFLIILSIL FQVIEISGHS PDPADYIAFS IPRAPRALII VRFFNVLITI
SLPKSVARRC KRQIWAVTLF LLYFMAFGSI IGVQLFGRKN YYCVKNGADL NNVSYNDLLL
TDHRCSNDTG ERGYICPGNF SCVSVDFDKR DKNYFGDFLH SILTVYESST QEGWVLVMYR
MTDFRSRPLV YIYFVLLIFF IAWLVKNVFI AVVSETFADI RSLYMYSRKS SKRTSARLAS
QVIKDGGTGW HLVSLDHEAH KGHAPLPVRQ LVNSDYFKYT MIVFVVVDAI VQATSVNFPR
RRYPQFGFTI LFDLEVLLKI SCMGFRPYLL RRMQLTEFIL AIGSTVFALP LLISEKAAFL
AFFNVMRIIR LVGAIPSLQE FCEKIFGTGK KLGAAIIFTL LFVMVSSVIS MQFFLTLDPK
NFGTFMKSVQ SMFQIITQEG WVEVLDGLIH ATTNTFARIL VAIIILACHL FSSLIIMSVF
VAVILDNLEL DEEVKIMKQK KIGQESREST EVLPLRLRVF ERFRDDPRLV KMSRIKMSAD
FSTPKIRDSF MKKFIDSTSL ETALAVDPRK QLGETSQLRR RRTAVPLKLL NSTVSEVDKL
SKFVRKQSSI TALINDSNRR RTYALLSPTE ISPRSAAIQG SNNNKQQPTS VFRSASRRFR
SRPPPSPKPA QGNPQVMRMA SQAAGLHAQL NQDDTNIGRD FDIQWVRVRR EEVQRKKKAQ
IDKLRENHPY FDQPLFSLQR DSWFRRFLQS LVSARFMIPP GYTERASRNH IVTMARLHKC
LASQTYLEWI MILVTLISCV AMLLETPTQR TFVNSSTEVV EYIFVIAMSL ELGVRILANG
LIFTPNAVIQ NFGGVLDVTT YLVALAYVAW QPHRIPACSG AQVLMVFRCL RPLRIVTLVP
KMQKVILELV GGYKEILKVS ALQLLLMFIF ASYGVQVFAL KFGSCNDRTI NTRKDCSGTF
EIEIAPPREL RDLPGASKIL VPRVWKNPRN FDFDNVVNAF LALFEVLSLE GWLEVRDVIQ
AVVSPEYSLY VHIYVLIGSM IGLTLFVGVI VMNFNENKGI ALLTVDQRRW QDLKKRLRLA
QPLHIAPRPR KEGIRTVLFD ATQSRIYKVF EITLVVVICL TVTIAQWTTE DNLRLRDGLT
STAAACSILF VVDMVLKIIA FSFQGYWQSR RNRFDLFLTS LGVLWATLNF SLKERGTPYT
VTTVFGMVII LFRFLTLAGK HDTLKMLMLT VVMSLVKSFF IIAVLIIIMV SYSLAGVILF
GTVKYGEALN RHANFKSSFN AMILLFRITT GEDWNKIMHD CMISEPYCTA GTPDTLNFWQ
SDCGNSAAAH IYFISFYIFV TFVFLNLFIA VIIENFSLFY SSDEDSLISN TDLKDFQLTW
NLVDKSRKGV LSVRQAKLVL RLLKGRLEVD TGSLLFKHMC CEIEKLRNGC DVSFHDVLGV
LAYRSVDISR SLQLEELLER EELEYQIEEE VAIQTIRDWF VNLRKKRAER EWIRHLEQGG
IPLAGGVQFD KSPGASSVES LEHSANDDQD REDRDTEREI RDHESSEDDD ISLSSPSKGP
AILLSAPPPV MKTDRSISPS RKNSVTFPEE VPMSSKRRKS LPETLANPKT RKKSLTEVKE
FAGEAVFRFE AGMGSISSAP VAPDSGASVA VVTQIPSAGC PVQHSTPAPS VSECPAHQSS
NVKVQASQCP ISGGAGCDSA ALDNSSDALD PSNMMPPPNQ QPSSGQPFPL PINRQVSSIP
RGGTGKDENW VYPSQQMFWN AMLRKGWKWQ EDEVQANDMA NIIRIHNANN ESAWQEILKW
EALHANECGT PRLLSFKGKA KEFSPRARIR NWLGYELPFD RHDWVVDRCG REVRYIIDYY
DVGDEEAYKR GEFVALDVRP AMDSFQAVLD RARIAVLRWT LYFRSGNDE
//
