ID A0A2B4SVB6_STYPI Unreviewed; 1318 AA.
AC A0A2B4SVB6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Cyclic nucleotide-gated cation channel alpha-3 {ECO:0000313|EMBL:PFX32482.1};
GN Name=CNGA3 {ECO:0000313|EMBL:PFX32482.1};
GN ORFNames=AWC38_SpisGene2681 {ECO:0000313|EMBL:PFX32482.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX32482.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX32482.1}.
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DR EMBL; LSMT01000022; PFX32482.1; -; Genomic_DNA.
DR EnsemblMetazoa; XM_022923376.1; XP_022779111.1; LOC111320703.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 135..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 790..893
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 148969 MW; 5CFDE42D49A42B7F CRC64;
MQRPSNLTPD ESPLTGVNHA SGQEEAAGPQ IPRVVIESTG QTRFASSVLR VLSMQRFYKK
TGRRSRDSWL ERYTGTYQED RDWRRPLMRR SASNSPQVQS PTSEGTGSSR DASDARLDQG
SCNCTPVFDP SGDLYFFWLI VVVLGILYNY WTIIFRVAFF VREQKYVIPF MAIDYSCDFI
FLLDIIVQFR TGYFLDGKIV TDTKQLAKHY VKSRGFFLDC VSILPIDLLF LVLGPRPALR
FGRLLKAHRL FLFCDRVEIY SGRPKLFNLL KQIHYLFLII HWVACFYFLL SYMEGFGADK
WLHPMLQGQW EEVGPQYLYS LFRSLVSMTT VGTGKQVSPQ TTMSLMFCIF TYLCGVLIFA
TIVGNAADMI VDLRRHREKY HRKGHDPRKW LVADKETLKR RLSLIEAKNE VRALASRFRR
ENGNSTNPRE IVAAIAERAR QERPDEDARK VIKEFLAKDR GSKIHKRSTM SHESLLANRS
HYADSGRENC LNDASDAENC ANDQTRKSQR RFFSRPHSRT LESKPASPTG NDIPLLTFKE
NDGILDQKSG SQPKDHSSNP VAFTLNSTKE KGIRPPVPKK GILKRASGES SSWRSSDSME
TSLSALENAK SNEENLTPSG QKNSTRSEKN IEENAKIPKQ KSKFKVPFLK EQKQDDVKIL
LATPENSEIV EDSPKLDRAA NRMKFTEKNP FTEIKLISEL DFIAPDKRCA CQQEAGTKNE
RLSPNCLDSE CQSAAQKNYS SAGSCPSMPA VIDPGKGDSM ILTAVLQLND NIRAEIAIHV
NLDTLKKVKM FEHCDPGFLR ELVLKLKPML CSPGDYVCRQ DEIGREMYIV NQGELAVVDK
RGAPLAKLSA GRHFGEISIL DIKGIGNRRT ASVRSVGFSD LFRLSKADLE EVLAFYPEEK
EQLAKIARQT YEKQRRERLN QKVDNDNLDK DQSDSRLQGH DPRKWLVADK ETLKRRLSLI
EAKNEVRALA SRFRRENGNS TNPREIVAAI AERARQERPD EDARKVIKEF LAKDRGSKIH
KRSTMSHESL LANRSHYADS GRENCLNDAS DAENCANDQT RKSQRRFFSR PHSRTLESKP
ASPTGNDIPL LTFKENDGIL DQKSGSQPKD HSSNPVAFTL NSTKEKGIRP PVPKKGILKR
ASGESSSWRS SDSMETSLSA LENAKSNEEN LTPSGQKNST RSEKNIEENA KIPKQKSKFK
VPFLKEQKQD DVKILLATPE NSEIVEDSPK LDRAANRMKF TEKNPFTEIK LISELDFIAP
DKRCACQQEA GTKNERLSPN CLDSECQSAA QKNYSSAGSC PSMPAVIDPG KGDSMVTK
//
