ID A0A2B4T2C8_STYPI Unreviewed; 2319 AA.
AC A0A2B4T2C8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0000313|EMBL:PFX34775.1};
GN Name=Pkd1l2 {ECO:0000313|EMBL:PFX34775.1};
GN ORFNames=AWC38_SpisGene266 {ECO:0000313|EMBL:PFX34775.1};
OS Stylophora pistillata (Smooth cauliflower coral).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Pocilloporidae; Stylophora.
OX NCBI_TaxID=50429 {ECO:0000313|EMBL:PFX34775.1, ECO:0000313|Proteomes:UP000225706};
RN [1] {ECO:0000313|Proteomes:UP000225706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Voolstra C.R., Li Y., Liew Y.J., Baumgarten S., Zoccola D., Flot J.-F.,
RA Tambutte S., Allemand D., Aranda M.;
RT "Comparative analysis of the genomes of Stylophora pistillata and Acropora
RT digitifera provides evidence for extensive differences between species of
RT corals.";
RL bioRxiv 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFX34775.1}.
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DR EMBL; LSMT01000002; PFX34775.1; -; Genomic_DNA.
DR Proteomes; UP000225706; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000225706};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1292..1312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1501..1519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1544..1565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1598..1621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1633..1660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1724..1746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1989..2010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2022..2048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2081..2099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2119..2141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2188..2207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..93
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 92..135
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 143..295
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 300..1028
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1337..1454
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DISULFID 125..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1829..1843
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2319 AA; 260276 MW; 04C832F99EC194F7 CRC64;
MYLETKGLRV VNRSQTSITV SWNPMESVSG YTIKYDKINN PEYIIVRSET TFEITGLEIN
TIYKIQVGGL KDVDGEEKPE SYSSILEART LSNDLCDSSP CQNGGTCQDG GPPSSESSLP
MYCQCAEKFS GRFCAVPKDS ADCQTALGME NYGIPNERVQ ASSEWKFDKA IHGRLHFQSR
SGNQGAWSAK TKDANQWLQI DLGSVFTKVT GVATQGRYMY DQWVTKYKVQ FSNGGSTFTN
YKEPGQAADK VFDGNTDQNT VVKHFLHAPF RARYIRFQPV TYYERISMRV ELYGCSDFVC
QSPDVILPNI SPNASSNISI HRLRQFTIQS DVKFNCNIYY KASFLWRIYQ LGKEETLLLS
RNSFSELQIT PHLLPVGEFL VRLNVSLIGT AVFGVGHGYF KVERSPLVAF IAGGNKVAKG
LDRTLIFDAS LSYDPDEKSL RFSGLNFTWQ CKESPRHLNN SDEPGCHYRA DDKETVGYEL
RINNSLLAEN TSYFITVQVT KHERQAVYTQ EVFIVPGDPP EVQIRCVENC AAKLNPSGIM
ALQGMCTGAS CHGNLIFEWT ALKDLNNSSK SSHWAEISHI QELISTRVSS KSFVTRPEVL
TPDTRYKFIL TAQRPGGNRG FSEYHVTSNS PPVGGVCNVS QTSGVTLITE FTFACNNWQD
PDLQLQYEFI YLIDDNIFNV AYKGVKKSLT TKLPAGGRKN NFTIDFRVRV ADILGAYTEV
RTPVQVSEPT FEPKDLVDMV ASLTSRDESE LNSLIKSGDV SRAAQLATAV LSVVDVVTQA
ESAESQMKSN IIQQLSAVPV DTVVRVQQVS YVIASASSVI GEITVEAQKA ATEALEKMTV
VLKTESTAGQ SYDTLFDGAK SLVTGLGSML RVTSHEASVD DAASKEESRL KASFITAYEG
RLPKSQRRNL KSRISLSDVL TRTKRDGADL RLQARVKVET LLHSLEEVGS TILSRTLVGE
EPKVLPAQAM SLLLLRQEPN LVAGTVLSNK GNSFRLPPVS KLFDNSTQFL DSQMVTTDFI
PFSWDPSGAR VTTAVSSLEL KNSSGHLLNT TELIAPITLR LQSHQKFTNA SQFHYVGSNR
TVFYKVNVNQ SGMALLLNIR PESNKTEFVV TVKYGERPSP SNSDLNLTLP DLSSCNKVPD
GYVNCSSNPY VVFVNQDFVE NKGFGYYFFG LRAVSRISRV KRCSGHGRSK RSCVQYKEPP
TMGPSYSVPQ YRVGDENYTI QVMPAACLFW NAELSKWTSE GCQVAEMTTQ DAIYCSCNHL
SSFGGQLFVT PNPLDFDKVF IELTRLPDSG NIAVILAVSC VFGLYLSLLL WARKNDKLDN
LKVGEKAFVG VPSEGSHFIE VQVSTGIWRN SGTTANVFVI LEGEIGTSRP YHLKDDSSIP
FARGSIISFI LAIHDSIGPI RTVRVWHDNS GNSPSWFLNH IKVCELTNKK QWNFVCFAWL
AVDRGDGLID RTLRGTSTVD KGIDFAVYVQ NRIAGEFSDS HLWFSVATRP PRYRFTRAQR
LSCCLSLLLT TMLASAMFYE RETAMDDNQG SLRLGRFVVN FREFIIAVQS LMVVLPVNIL
TVALFTHTRS SNENKEMALQ SNSHKKLARK SDISFPHWFI FVPWLLCFLL STCTASFVVF
YSLQWGADKS EQWLVSVAMS VVLDIFVSKP VQIIVVAFML SHICKGGIQR FTRQPYHADA
IVDVEDIKLS WLGNEDTDEE EIEIPKPLSK RQLRRARIAR MREVYMYTAL RNIVSYMLYL
LILFIVCYGG RSQHGYLMTS TLKTTFGKLD SITNYFKTWD WARDVLVPGL FDDGKNLILN
SHSLYIGSGD AVLVGMPRFR QLRVKEGSCD VSIEELKPPF NSCVATYTSN NEDKSSFHRT
RWDQFSSSRN DSLNILYQIC PTAWHYSSAE RTQSLPLWGK LHLSNFYGEG GYLAELGYDK
ATALKVISEL KLFDWIDRFT SAIIVEFTVF NSQVNLFGVI WIPIEFSPSG HVVSDPVIRG
IHVYEIGGGY SAVTVVCQLL LVVYIIYFVV KETSKMIAGV RMYFAQFLNW VELTQTLTVI
GFVVTHIFKQ AELFYNTEKL RNNTFQFISF DKGAFLEDLE TVLISLLMFL NTLKLLYLLK
FNPHVRHLFY VMKGSARELV NCSVAFTLFM FACIHVGYFL FGSELYPFSS PVITLQSLLV
EGVLGGRFDY FNDCCTVTGP VYVTALKLGL NLIFINVFVS VLVYNYGNIR DLTRGKFNLG
NFIIVKIKEL MGFGVHSSAM DADSSCDPNT KNEENALPEV DEILTKLDRI NHHLNVLYAD
EFGEDLDMFS LWFDLHMQRL EAKDTQRNEN DAEKDLEDA
//
