ID   A0A2B7GUJ3_9EURY        Unreviewed;       453 AA.
AC   A0A2B7GUJ3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:PGF16561.1};
GN   Name=thiD {ECO:0000313|EMBL:PGF16561.1};
GN   ORFNames=CP556_10815 {ECO:0000313|EMBL:PGF16561.1};
OS   Natrinema sp. CBA1119.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrinema.
OX   NCBI_TaxID=1608465 {ECO:0000313|EMBL:PGF16561.1, ECO:0000313|Proteomes:UP000223005};
RN   [1] {ECO:0000313|EMBL:PGF16561.1, ECO:0000313|Proteomes:UP000223005}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBA1119 {ECO:0000313|EMBL:PGF16561.1,
RC   ECO:0000313|Proteomes:UP000223005};
RA   Roh S.W., Kim Y.B., Kim J.Y.;
RT   "Genome sequences of Natrinema thermophila CBA1119T.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGF16561.1}.
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DR   EMBL; PDBS01000001; PGF16561.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7GUJ3; -.
DR   OrthoDB; 43786at2157; -.
DR   Proteomes; UP000223005; Unassembled WGS sequence.
DR   GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR   GO; GO:0004789; F:thiamine-phosphate diphosphorylase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR   CDD; cd01169; HMPP_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR   InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR   InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR019293; ThiN.
DR   NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR   PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR   PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 1.
DR   Pfam; PF10120; ThiP_synth; 1.
DR   SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:PGF16561.1};
KW   Transferase {ECO:0000313|EMBL:PGF16561.1}.
FT   DOMAIN          19..261
FT                   /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   453 AA;  47411 MW;  CC5211E74A3E0EF9 CRC64;
     MRTPAPEHRP VGLTIAGSDS GGGAGIQADL ATMAAHGVFG TSAITAVTAQ NTRGVESSHV
     LPLEAVEAQL AAVTDDFAVG GAKTGMLATA DIVRTVADRA SEFDFPLVVD PVMVATSGDR
     LLEPEAERAY EDLLGEATLA TPNVDEAEVL TDVAVVDEET AREAGDAILE TGVDAVLVKG
     GHVPGERVQD VLVTDDTVRT FEHPRVGTDA THGSGCALAA AIAARLAKGE ALEPAVAGAT
     DFLARAVRYY SDVGEGHGAV NHMVPLRNEA AREPTAEEVQ AIVDRFVDAD ISALVPEVGM
     NVVGATPYAE SVTETAAVEG RITRTLSGVQ PNRGVRFGAS SHVARFLLSA REFVPDLRFA
     VNCRFDADVE AALESLEWPV ATYDRDTEPA AVKETEGSTM GWGARQAFAD REEAPVAVID
     RGEVGKEALV KLIAADPETL ADRTLALDRE VTE
//