ID A0A2B7WFS6_9EURO Unreviewed; 1186 AA.
AC A0A2B7WFS6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 26.
DE RecName: Full=Cell division control protein 25 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GX51_08257 {ECO:0000313|EMBL:PGG95409.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGG95409.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGG95409.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGG95409.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGG95409.1}.
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DR EMBL; PDNC01000233; PGG95409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7WFS6; -.
DR STRING; 2060905.A0A2B7WFS6; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF341; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000224080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 84..143
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 756..889
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 925..1161
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 151..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..179
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 132139 MW; D78265B0F1669615 CRC64;
MYSSRSAVPL TANSKSVLNT KPGTFAAAFH YTEDETPAHD DSHYHSTNDR SYHADMARHH
GNDGYVTNNN RGTEEVYNSP VDSQPALYVR ALYNYTADDH TSLSFRQGDI IQVLNQLDTG
WWDGVMGDVR GWFPSNYCAV VTDPDSIGLG GGHFGHEGAD TSAESGADDY DDDEDVDSDG
NPKDERSILP IEGTRGSEHE EAAFWIPQAT ADGRLFYFNT LTGRSTAELP LESPMSATDT
GPRDRTNIFV PEQTRPPPEL MVGGIDRDED DYDGSGSEAE DSINAEPIAK PYSESNHKRQ
SPHTSSSQLA PNNGMISSAP NAQSTHMERL SAQSISSIIP RHFLDDGSSA PLTWNKLVGN
MRQAIDAYRR AIMEGHRAQY VRRAEDISDH LRMLLAAGSD TTDNHSGNPS IISTNKALYP
HFRDMMSKFS KLVLSSHIAA ADWRGPDSDA KCLQEAEGVL HGVYGYVEVA KQQRGDDINR
LVPGFVQGSG SGGHWQNNNV GIRNPTAFLD HENRDAGHEP AMVLDSNIVD RIESLKDMLA
ASVRRLEENL SLSEKTITPR IHLAIADAVC AAGSRVVECF QPWISLVESI DLAPLERGSQ
NPQLVDFSLQ KQRAYDGVAD LVLSCQSVSA PLGDEWAELR GDTLETRLAS VRSVSRQLQN
YMTQIGFSLT LLLEQAPSEA PPARDIGSGA GSSNVPSGSI GVPSTYAPAD RQPVKSRANI
DKAQRFFGDT IPTEPTTPWF LNIDHESEVF YDNKGDSPSL KCGTLAGLVE HLTRHDKLDT
SFNATFLLTY RSFTTASELF EMLVHRFTLQ PPYGLDKADL QTWTEQKQIP IRIRVVNIMK
NWFENYWMEP NDDVNMRLLQ RVYSFVKDSV GKTKTPGTQQ LLSLIDQRMR GQDTTAKRLV
PTISGNTPPS ILPKNLKKLK FLDIDPMEFA RQLTIIESRL YAKIKPTECL NKTWQKKLAP
DEPDPAANVK ALILHSNQLT NWVAEMILHQ QDVKRRVVVI KHFVLIAERC RAMNNYSTLT
SIISALGTAP IHRLSRTWAQ VSARISAVLE NMRRLMASTK NFGEYREALH LANPPCIPFF
GVYLTDLTFI EDGIPSLTQS HLINFNKRAK TAEVIRDIQQ YQNAPYPFHP VPELQDYVLS
NMQAAGDVHE MYDRSLEIEP REREDEKIAR YGRMNDASVF ALMIST
//