ID A0A2B7WGV5_9EURO Unreviewed; 1105 AA.
AC A0A2B7WGV5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Nitrite reductase [NAD(P)H] {ECO:0000313|EMBL:PGG95842.1};
GN ORFNames=AJ80_09904 {ECO:0000313|EMBL:PGG95842.1};
OS Polytolypa hystricis UAMH7299.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGG95842.1, ECO:0000313|Proteomes:UP000224634};
RN [1] {ECO:0000313|EMBL:PGG95842.1, ECO:0000313|Proteomes:UP000224634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH7299 {ECO:0000313|EMBL:PGG95842.1,
RC ECO:0000313|Proteomes:UP000224634};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- COFACTOR:
CC Name=siroheme; Xref=ChEBI:CHEBI:60052;
CC Evidence={ECO:0000256|ARBA:ARBA00001929};
CC -!- PATHWAY: Nitrogen metabolism; nitrate reduction (assimilation).
CC {ECO:0000256|ARBA:ARBA00005096}.
CC -!- SIMILARITY: Belongs to the nitrite and sulfite reductase 4Fe-4S domain
CC family. {ECO:0000256|ARBA:ARBA00010429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGG95842.1}.
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DR EMBL; PDNA01000398; PGG95842.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7WGV5; -.
DR STRING; 1447883.A0A2B7WGV5; -.
DR OrthoDB; 275583at2759; -.
DR UniPathway; UPA00653; -.
DR Proteomes; UP000224634; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008942; F:nitrite reductase [NAD(P)H] activity; IEA:InterPro.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-UniPathway.
DR CDD; cd19944; NirB_Fer2_BFD-like_2; 1.
DR CDD; cd03529; Rieske_NirD; 1.
DR Gene3D; 3.90.480.20; -; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 1.
DR InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer.
DR InterPro; IPR036136; Nit/Sulf_reduc_fer-like_dom_sf.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR InterPro; IPR012748; Rieske-like_NirD.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR NCBIfam; TIGR02378; nirD_assim_sml; 1.
DR PANTHER; PTHR43809; NITRITE REDUCTASE (NADH) LARGE SUBUNIT; 1.
DR PANTHER; PTHR43809:SF1; NITRITE REDUCTASE (NADH) LARGE SUBUNIT; 1.
DR Pfam; PF04324; Fer2_BFD; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF03460; NIR_SIR_ferr; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF13806; Rieske_2; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00397; SIROHAEM.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF50022; ISP domain; 1.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 1.
DR SUPFAM; SSF55124; Nitrite/Sulfite reductase N-terminal domain-like; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000224634}.
FT DOMAIN 935..1039
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 1105 AA; 123246 MW; 3416AE70B6C1B92E CRC64;
MDSLIMDSGI VAESNFTNVV HINGIDPIHH DIKGPPNGYP NRRKKLVIVG LGMVALGFIE
KLLKLDGKQR LYDIVVIGEE PHIAYNRVSL SSFFEHRKVE DLYLNPKEWY GSFGDGSLSY
HLNTKVTEIS AVNKQVRTST GGLVSYDLLV LATGSDAILP KRTPGYDANG VFVYRTIDDL
ERLIDFSTKH KGNVGVTVGG GLLGLEAAKS MMDMDVFSSV KLVDRNRWVL SRQLDGDAGS
LVTDKIRDLG LDVLLRKRVT RINVDDGNNV TGITFEDGES IDCCCICFAI GVRPRDELAI
AAGIECAENS GLVVSEFLET SEPDIYAIGE CASWENKTFG IIAPGIEMAD VLSFNLTRAP
DQEPKRFKRP DLSTKLKLLG VEVASFGDFF ADRDGPKSLP NNHRMALNGN TASREPVSPV
KALTYKDPFG AVYKKYLFTP DGKYLLGGMM IGDAKDYIKL NQMVKNQKPL EVPPSEFILG
AQKGEEDSID DLDDDTQICS CHNVLKCDIV DNVKNGKCKT IADIKICTKA GTGCAGCMPM
VQSIFNKAMQ DMGQEVSNHL CPHFPYSRAD LYNIIAVKQL RDFVVVMKAC GKRPDSLGCE
VCKPTIGSIL SSLFNQHIMD AKLHNLQETN DRFLANIQRN GTFSVVPRAP GGEITPDKLI
VIGQVAKKYN LYCKITGGQR IDLFGAKKDD LLDIWKELVD AGMESGHAYA KSLRTIKSCV
GSTWCRFGIG DSVGMAVRLE HRYKSIRSPH KTKGAVSGCV RECAEAQSKD FGLIATEKGY
NVYVGGNGGA KPRHCDLLAK DVSPEEVVKL IDRYLIFYIR TADKLQRTAR WIENLPGGIN
YLKEVILDDK LGICTDLEKQ MEELVNSYFC EWKEALNSDE RRKHFKQFGN TDETVETVEV
IKEREQERPT YWPQKSAEED FKGHKWSVTT WQPMIRAVHF SDVPPEISSA NVKRGNTQLA
IFKIKGKYYA TQQMCPHKRA FVLSDGLIGD DDAGKYWVSC PYHKRNFELN GEQAGRCSND
EALNIATFPT EEREDGWVYL KLPPVEELDK LLATDKWKVR KEESPQSPFD RMDKKYKGLR
GKKAKELLNG VAHVRQSITT NGIDW
//
