ID   A0A2B7WGY1_9EURO        Unreviewed;      1062 AA.
AC   A0A2B7WGY1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=GX51_08124 {ECO:0000313|EMBL:PGG95771.1};
OS   Blastomyces parvus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGG95771.1, ECO:0000313|Proteomes:UP000224080};
RN   [1] {ECO:0000313|EMBL:PGG95771.1, ECO:0000313|Proteomes:UP000224080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH130 {ECO:0000313|EMBL:PGG95771.1,
RC   ECO:0000313|Proteomes:UP000224080};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGG95771.1}.
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DR   EMBL; PDNC01000207; PGG95771.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7WGY1; -.
DR   STRING; 2060905.A0A2B7WGY1; -.
DR   OrthoDB; 614488at2759; -.
DR   Proteomes; UP000224080; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07216; Pat17_PNPLA8_PNPLA9_like3; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46082:SF11; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   Pfam; PF13374; TPR_10; 2.
DR   Pfam; PF13424; TPR_12; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000224080}.
FT   DOMAIN          24..225
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   1062 AA;  118619 MW;  FD8350123CF9F5AE CRC64;
     MEQATFIKNG DDPNPLDTTG LCLLSLDGGG VRGLATLYVL KSIIDRLNNE RMKESLAPVK
     PCEVFDLIGG TSTGGLIALM LGRLEMTVDE CIAAYSDLAE AVFSEHRTLF PFNFTGRVKS
     RFDSARLESA IKLAVAQAGA SETNLFNDGT ERGCRTFVCS IDRDTKDMVR LRSYSLDDEP
     TIPATVCQAA LATSAATTFF DPVSIGDRNF ADGGFGANNP VDEVEGEAAN IWCPETGDLK
     PLVKCFISIG TGNPGKEAFK DNIVGFLGET VVRIATETEA TERKFIARWA KHFDEKRYFR
     FNVEQGLQDI GLEEYKRKGA IEAASEGYLT HMAQKLRVRD CIQNLRLKKS TAATNLSNFI
     AEYNGRRMLE LPIKSPTKVH STIPFERNPR FVGRAAEIDK IHDVLASETR CERVAIVGLG
     GVGKTQIALE FTHRLQERQL DCSVFWIPVT SVESMLEAYL EIGRQLQIPN LEREKADILR
     LVQLRLDEET SGRWLLVFDN ADDIEMWMEK ASDAGNSGNC GRRIDYLPKS KHGSILFTTR
     NLKAATKLAG NNFVLVGEMD DVMAKDLLQR SLFDRNLLTD DQAATDLLKK LTHLPLAIVQ
     AACYINANGL RTLTEYTTLL DDTEENKIDL LSEDFEDLGR YRDAKNPVAT TWLLSFEQIR
     KRDQLAADYL SFMACIDAKD IPQSLLPPAP SAKKATDAVG TLSAYSFITR HTTGQTGQTD
     QLLDLHRLVH LATRNWLRME GTFEQWAATA LERLEQVFPD LDHRKRSVWR TYQPHARCAL
     ELKLEGAEST RINLLWKFGK CALSYGMYRD AEKAIAQVME TRKKKLGVDH PSTLVSIDIL
     ALVYSRQGRL DAAEELNVEA MKIKKTNLGA DHPDTLVSMT NLASIYWTRG RLDAAEELNV
     QAMKISKTIF GADHPYTLTS MGNLANTYRS QGRLDAAEEL GVHVMKTLKE KLGADHPATL
     SSMSNLALTR KRKGQDAEAI SLMRECVQRR QHVLGLNHPK YKFALSTLTR WEAEQADAGA
     TAGRNVVENE RKVLANSLPQ KNKATTPIEE QVFQIRKKFR HN
//