ID A0A2B7WHK5_9EURO Unreviewed; 682 AA.
AC A0A2B7WHK5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=GX51_07913 {ECO:0000313|EMBL:PGG96245.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGG96245.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGG96245.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGG96245.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGG96245.1}.
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DR EMBL; PDNC01000184; PGG96245.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7WHK5; -.
DR STRING; 2060905.A0A2B7WHK5; -.
DR OrthoDB; 2045814at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:GOC.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0033260; P:nuclear DNA replication; IEA:InterPro.
DR CDD; cd14516; DSP_fungal_PPS1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR047949; PPS1_DSP.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR47550; DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1; 1.
DR PANTHER; PTHR47550:SF1; DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000224080}.
FT DOMAIN 503..652
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 571..639
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 76719 MW; 67F5390DC21E9A00 CRC64;
MATVVVQQQP VRHSSSPPPI TSALSLSANS SHSPPPVPNK HLPVCPPGPA PASSKIPATP
PASPTLRHST PLQGNCVLYP PSSFPKLCDD PPVYSIDADT LAHALDELAS RPLPDPKQVF
PWLHGLHPDN HIQLGFFVSR RRSLRRIPRC LRSIAIVKLG GDLSRSRIKG AIAPEEILSP
SGTTFIDADP PEGFSVRNFH IQTAKLAPLS DVIVYAEDGA NGSELLELAD GIARAQKEWR
RRFDPGQENS LFNTFILRSS FNEVEARHPE LIAVNCQGQL TGRVMDFFHW ERLEMCKMAE
ASEITTNVWQ GPTPDINERP LQDLGFDVFI EAHDVANIPN IRYLSKISRQ MNDGPQRLEF
PSSGSVLASF NQVEVFDLID TCRWIYHITH PEQLEQPVDS DGDIPMVELA SKPRKVLIHC
GDGYTESSLL AIAYFMFAEG VPVHEAWLRL HCEKKRNFFA YPSDVTFLTS IQQRLLLESP
AARNRSIPNS LEPAWLSRMD GSLPSRILPY MYLGNLTHAN NPELLRALGI KRILSIGESV
SWPPSEIEKW GLESLMMINE VQDNGIDPLT QQFDRCLKFI EKGKKDGTAT LVHCRVGVSR
SATICIAEVM ACNRLSFPRA YCFVRARRLN VIIQPHLRFV YELLKWDELL RQKRHEPIRR
DLEWVTIARE IALMNKPYSK QQ
//
