ID A0A2B7WRS5_9EURO Unreviewed; 1068 AA.
AC A0A2B7WRS5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=GX51_06391 {ECO:0000313|EMBL:PGG99197.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGG99197.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGG99197.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGG99197.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGG99197.1}.
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DR EMBL; PDNC01000104; PGG99197.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7WRS5; -.
DR STRING; 2060905.A0A2B7WRS5; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:PGG99197.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000224080}.
FT DOMAIN 474..692
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 117891 MW; 896AE61193F90ECA CRC64;
MAPKKKGSKK QQEDWEAELG ETIPPTTGTD DAATGEDGND AANNANDNNN NDDDGMSGGL
LATLKKNRNK KAKKGKGGDN DFVEGEDPTA AAAAAESKQP QEASFEDDED DVFSGTAAAR
QRAKDKAAAM KEKAKEAEEE GGKLKSKKEK EKEKKEREKQ RKREQAAKKK ATTTPAAAPA
TNAEPAKPAV EEKPAAPAAP AAAPAADTAG KKRKLPAHLA AIQKQQEALR KQQEEIARLE
AEEKAAAEEH QRRLEEEERK KEEARQRKKE KEREKKEQLR REGKLLTKAQ KEAQQRNELR
KQQMLAAGAV VPGLEEPLEK KKPVYENRKK RPVKKQEDDL EAAAARAEAQ RLELEAEKAK
KAEEERKRAE EKAAAKAAAQ AAAKEAEDDD IKESWDMSSD EEGGEKREAD QDEESGANGA
AKGETSPEES EEESSEDEEA TAAQRALAQK KAEAAERRRR QHEEALAARS TDNLRSPICC
ILGHVDTGKT KLLDKVRQTN VQEGEAGGIT QQIGATYFPT ESLKQKTAVV NKDGSFEFKV
PGLLVIDTPG HESFSNLRSR GSSLCNIAIL VVDIMHGLEQ QTLESMRLLR DRKTPFIVAL
NKIDRLYGWK KIDNNGFQDS LALQSKGVQN EFRDRVEKTK LAFAEQGFNS ELYWENKSMA
RNVSLVPTSA HTGEGVPDML KLLVSLTQER MTKQLMYLTE VECTVLEVKV IEGLGTTIDV
VLSNGVLREG DRIVMCGLNG AIATNIRALL TPAPLKELRL KSQYVHNKEV RAALGVKIAA
NDLEHAIAGS RLLVVGPNDD EEDLEDEVMS DLENLLSKVS KDNRGVSVQA STLGSLEALL
EFLRASKIPV ANISIGPVYK RDVMRAGTML EKAKQFAVML CFDVKVDKEA QAYADEVGIK
IFTADIIYHL FDDFTKHMEQ IAEQKKEESK LLAVFPCVLN TVAVFNKKDP IVIGVDVVEG
SLRLLTPIAA VKANPVTGVK EIINLGRVQS IEREHKQIPL CKKGQPSVAI KIEGPNQPLY
GRQLEEKDTL YSLISRPSID TLKEFYRADV SMDEWVLIKK LKPLFDIP
//
