ID A0A2B7WWB4_9EURO Unreviewed; 408 AA.
AC A0A2B7WWB4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Threonine aldolase {ECO:0000313|EMBL:PGH00738.1};
GN ORFNames=GX51_05619 {ECO:0000313|EMBL:PGH00738.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGH00738.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGH00738.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGH00738.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH00738.1}.
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DR EMBL; PDNC01000081; PGH00738.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7WWB4; -.
DR STRING; 2060905.A0A2B7WWB4; -.
DR OrthoDB; 178754at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000224080}.
FT DOMAIN 47..339
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 252
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 408 AA; 43867 MW; CA52580AF097E936 CRC64;
MPPSVSDIRS NLVSNIKSES MENDVNKPYT YSAMPNLKRA IQKAGGDFRS DVSTVPTENM
MQAILEASVG DDIYDEAGDA SVNALQNKLI ELTGKEAALW ALSGTMGNQI CLRTHLMQPP
HTVLLDHRAH VYCWESGALP ALSQASVSPV IPSNGIHLTL KDVKKHMVSG DNLHFPPTRV
VSLENTLSGT ILPLKDAKEI SAFVRSFPVP EGQKPIAMHL DGARLFDGLA GEGVDPKEYC
ACFDSISICL AKGLGAPMGS VILGSRAFIE RAKWFRKMFG GGTRQPGMMA AAAQAALTAS
IPQVPRVHAL TKSTASKLAA CGYKFQLPVQ TNMILIDLEA SNDIPPAAFV SYCTAQGLQV
FPSGRLVFHY QTSEEAVGRL VGALERLMLD KKGGKELENG EVKGGYRT
//
