ID A0A2B7X174_9EURO Unreviewed; 679 AA.
AC A0A2B7X174;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Pre-mRNA-splicing factor CLF1 {ECO:0000313|EMBL:PGH02580.1};
GN ORFNames=GX51_04607 {ECO:0000313|EMBL:PGH02580.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGH02580.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGH02580.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGH02580.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication. {ECO:0000256|ARBA:ARBA00037040}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the crooked-neck family.
CC {ECO:0000256|ARBA:ARBA00008644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH02580.1}.
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DR EMBL; PDNC01000058; PGH02580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7X174; -.
DR STRING; 2060905.A0A2B7X174; -.
DR OrthoDB; 5479069at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246:SF3; CROOKED NECK-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR Pfam; PF02184; HAT; 2.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 15.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000224080};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 72..105
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 515..565
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 679 AA; 81973 MW; A7E3F8FE743B160E CRC64;
MEASRGPPRV KNKAPAPQQI SAEQLLREAV DRQEPALQAP TQRFADLEEL HEYQGRKRKE
FEDYVRRNRI SMNNWMRYAQ WELEQKEFRR ARSVFERALD VDPTAVVLWI RYIEAEMKTR
NINHARNLLD RAVTILPRVD KLWYKYVYME EMLGNIAGTR QVFERWMSWE PDEGAWGAYI
KLEKRYNEFD RVRAIFERFT VVHPEPKNWI KWARFEEEYG TSDLVREVYG LAIETLGEDF
MDEKLFIAYA RYEAKLKEFE RARAIYKYAL DRLPRSKSIA LHKAYTTFEK QFGDREGVED
VILAKRRVQY EEQIKENPKN YDIWFDFVRL EETSGDVDRV RDIYERAIAQ IPPSQEKRHW
RRYIYLWIFY ALWEELETKD MERARQIYQE CIKLIPHKKF TFAKIWLMKA QFEIRQMDLQ
AARKTLGHAI GACPKDKLFK GYIDLERQLF EFVRCRKLFE KQIEWNPANC QAWIKFAELE
RGLDDVDRAR GIYELGISQP VLDMPELLWK SYIDFEEYEG EYDRTRMLYE RLLEKTDHVK
VWINYARFEI NIPEGEEEEE EEEEEKPVSE EAKRRARKVF ERAHNVFKEK EMKEERVALL
NAWKSFEQTH GSPDDIAKIE RQMPSKVKKR RKLDDDRYEE YMDYMFPADD ESSAKLSQIL
QRAHQWKKQQ AGSMGKGEA
//
