ID A0A2B7X4J3_9EURO Unreviewed; 984 AA.
AC A0A2B7X4J3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Translation initiation factor aIF-2 {ECO:0000313|EMBL:PGH03780.1};
GN ORFNames=AJ80_08650 {ECO:0000313|EMBL:PGH03780.1};
OS Polytolypa hystricis UAMH7299.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGH03780.1, ECO:0000313|Proteomes:UP000224634};
RN [1] {ECO:0000313|EMBL:PGH03780.1, ECO:0000313|Proteomes:UP000224634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH7299 {ECO:0000313|EMBL:PGH03780.1,
RC ECO:0000313|Proteomes:UP000224634};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH03780.1}.
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DR EMBL; PDNA01000207; PGH03780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7X4J3; -.
DR STRING; 1447883.A0A2B7X4J3; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000224634; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:PGH03780.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000224634}.
FT DOMAIN 470..688
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 108319 MW; 2A6A9366AEBD29DB CRC64;
MAPKKKGGKK QQDDWEADLG ESITPTNEAA QDASPPADDN AAGEEDGMGG GLLAALKKNR
SKKAKKGKVV NDFVEGEDAA DGNTPDGEGT ATPVDLASKA PQEASFDDEE EDVFSGNAKK
GKQAAKGGNK KAQKDEEEGN TVKSKKEKEK ERKEREKQRK REQAAKKKSA TPAPAPTPKA
EAKPVAEAKP ADAPADESAG KKRKVPAHLA AIQRQQELLR QQQEEEARRT EEEKRLEAEF
KQKLEEEEQK KEEARQRKRE KEREKKEQLR KEGKLLTKAQ REAKERNELR MKQMLAAGAT
VAGLEAPTDE KKKPVYDNRK KRAPRKQEEV DLEAAAARAE EERKAAEEEK LKREAEEKAR
AEAEAAAAAA AAAEESDDDV KDSWDMDSDQ EAEEKASKKT KEVVVDGHAK PGANGAAADG
EEGESEEESE SEDEESTATQ RAIAQRKAEA AERRKKQYEE ALAARSKDHL RSPICCILGH
VDTGKTKLLD KVRQTNVQEG EAGGITQQIG ATYFPVDALK QKTAVVNKDG TFEFKVPGLL
IIDTPGHESF SNLRSRGSSL CNIAILVVDI MHGLEPQTLE SMRLLRDRKT PFIVALNKID
RLYGWKKIDN NGIQDSLAFQ GKGTQAEFRD RVEKTKLAFA EQGFNSELYW ENKSMARNVS
LVPTSAHTGE GVPDLLKLLL QLTQERMTNS LMYLSEVECT VLEVKVIEGL GTTIDVVLSN
GVLREGDRIV LCGLNGPIAT NIRALLTPAP LKELRLKSQY VHNKEVKAAL GVKIAANDLE
QAIAGSRLLV VGPDDDEEDL EEEVMSDLEN LLSRVSKDNR GVTVQASTLG SLEALLEFLR
VSKIPVCNIS IGPVFKRDVI RCSTMLEKAK QFAVMLCFDV KVDKEAQAYA DEMGIKIFTA
DIIYHLFDDF TKHMEEVALQ KKEENKLLAV FPCVLNPVAV FNKTNPIVVG VDVVEGALRL
LTPIVAVKQN PVTGAKEIIN LGRV
//
