ID   A0A2B7X8K3_9EURO        Unreviewed;       755 AA.
AC   A0A2B7X8K3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   03-MAY-2023, entry version 16.
DE   RecName: Full=FHA domain-containing protein {ECO:0000259|PROSITE:PS50006};
GN   ORFNames=GX51_03144 {ECO:0000313|EMBL:PGH05047.1};
OS   Blastomyces parvus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGH05047.1, ECO:0000313|Proteomes:UP000224080};
RN   [1] {ECO:0000313|EMBL:PGH05047.1, ECO:0000313|Proteomes:UP000224080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH130 {ECO:0000313|EMBL:PGH05047.1,
RC   ECO:0000313|Proteomes:UP000224080};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH05047.1}.
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DR   EMBL; PDNC01000033; PGH05047.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7X8K3; -.
DR   STRING; 2060905.A0A2B7X8K3; -.
DR   OrthoDB; 2787016at2759; -.
DR   Proteomes; UP000224080; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd22679; FHA_SLMAP; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1.
DR   PANTHER; PTHR15715:SF46; TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000224080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        728..747
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          190..247
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   REGION          1..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          371..398
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        45..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..453
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..550
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..587
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  82143 MW;  FD782BE4558E00D1 CRC64;
     MTAVASPPSV QSGPRLGWHP AVDGGQGALT PSSSDEGLRM FMPRKSVQRT NSSSSLNSNS
     STTSTITVNS QHSNASYTPN ESGTTTSKKK SYKYSWSNSK AEPVSGVTNA RSLPVSAPPS
     GTTASSAMSA LHQPTPVVPS QHALQNQQQN GTRLTNGALP NDPPAILTLL PVNGTFERKQ
     ITVPYFPEVL RVGRQTNAKT IPTPVNGYFD SKVLSRQHAE IWADRAGKIW IRDVKSSNGT
     FVNGQRLSPE NRDSEPHELR EHDTLELGID IVSEDQKSIV HHKVSAKVEH AGIYGPNMNI
     LDLNFGDIDP TAGGGLLPSH LSQPLSHMRG RPGSAASNRS NHSAAGNHMG MLHQQRQMNY
     WLSPISIEQV VKRLSSEMKQ AKQQAHDLNQ TNNFLSHLVS HEVLEKERAK LSPIESHGGA
     RLVNGRPKMT KVDQISRFSD PPAPPPQQPL PEKPDAPHRS ITDSVPQPSL KRSDTEKPKA
     PIHPSANRES SQILSLIEAL ATAQKDLDAQ GARVKELENL LLAERAAREH AEERARNLEG
     GADRGENSEV ETVCEPPAAS ENGHTVVEEI ALLEPSKPEE SKPTDDSTLP EPSETSPSTI
     SEQLQQRIDS MIAEMDEMKK EVAKYKQAAE KAENEASESR KTLAEMIEQV RSTRTEVPPN
     SSPEAIKIRL DNGQTEAGAL VDILNERLGQ ANLLHDAGST SRPLDQAGKE VYGTYVKQRH
     KNVLDHTAPY ASMLGVVLLG VGIMAYLNGW QRGDK
//