ID A0A2B7X9Y0_9EURO Unreviewed; 936 AA.
AC A0A2B7X9Y0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=GX51_02912 {ECO:0000313|EMBL:PGH05573.1};
OS Blastomyces parvus.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=2060905 {ECO:0000313|EMBL:PGH05573.1, ECO:0000313|Proteomes:UP000224080};
RN [1] {ECO:0000313|EMBL:PGH05573.1, ECO:0000313|Proteomes:UP000224080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH130 {ECO:0000313|EMBL:PGH05573.1,
RC ECO:0000313|Proteomes:UP000224080};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH05573.1}.
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DR EMBL; PDNC01000029; PGH05573.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7X9Y0; -.
DR STRING; 2060905.A0A2B7X9Y0; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000224080; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000224080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 369..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 457..479
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 533..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 562..579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 617..677
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 768..825
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 103496 MW; 3BD4EDDEB71CB5A9 CRC64;
MTPPRSSLSA HSLRPSQRRS SIHQPNTNSP TDNIPHHAHT PTTETPREGG AHTMPPPPPL
RDEIYEINEI KRYEDFTTID WVQDAVHEQA RRRAKRIDGS RFWDQEGTLG WRRKVRESYD
AGQAWLVITI VGAAIGLNAA FLNIVTEWLA DIKLGYCTTG FYLNESFCCW GADDGCPEWR
PWTPIAPLNY IAYFIFAVLF AFSSAVLVNS FAPYAAGSGI SEIKVIIAGF IMKGFLSART
LIIKSLTLPL SIASGLSVGK EGPSVHFAVC TGNVISRWFG KYKRNAAKTR EILTATAGAG
VAVAFGSPIG GVLFSLEEMA SYFPLKTLWR SYFCALVATG VLAAMNPFRT GQLVMFQVKY
DRTWHSFELI FFVLLGIFGG LYGAFVMKWN LRSQAFRKKY LSRHPIIEAT VLAGVTALIC
YPNMFLRINM TEMMEILFRE CEGAHDYNGI CNTNNRWSMV ISLAIATIIR ILLVIVSYGC
KVPAGIFVPS MAIGASFGRM VGIIVQALYE AFPDSKFFAA CEPDVPCITP GTYAFLGAGA
ALSGIMHLTV SVTVIMFELT GALTYILPTM IVVGVTKAVS DSFGKGGIAD RMIWFNGFPF
LDSKEDHIFN VPVSHAMTSK PVVLPATDFP VSKAEKLLRQ HKYQGFPIVE DLTNKVVIGF
IGRTELQYAI YRAKRAGLLA PNAKCRFTST PSASSHRHRN TVPSTNSLTL QIPSSNQQTF
GSNSSSSSRS EDHPFNSDRR PDDRPPSRTF DDIATSTGIR SIDFSQYVDL APITVHPRLP
LETVMEIFKK MGPRVILVEH RGRLSGLVTV KDCLKYQFKV EAQELTSTGV GVGPDGHGHG
HGSNGGLGEG IVEQKAWELI QWATEKVAFW RRVGWWRGRG GLLRLGSSQG ERDRRWESGH
EASEWDGELL QSRSSSDIVD GTEELEGFVE LEERGD
//
