ID A0A2B7XB28_9EURO Unreviewed; 568 AA.
AC A0A2B7XB28;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 08-NOV-2023, entry version 13.
DE RecName: Full=Dioxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AJ79_06633 {ECO:0000313|EMBL:PGH06099.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH06099.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH06099.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH06099.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH06099.1}.
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DR EMBL; PDNB01000120; PGH06099.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7XB28; -.
DR STRING; 1447875.A0A2B7XB28; -.
DR OrthoDB; 294919at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968}.
FT BINDING 220
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 270
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 341
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 554
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 568 AA; 61635 MW; 6C06D2CAFFA2E7EA CRC64;
MGAADNPPKS YNDWPNYQGF NSDYEERTPV ELKVTGDIPS WAAGVLYRTG TGRSEIETEN
KGTWKVAHWF DGLAVVHRFQ ILPPDADHPS VRVIYNSRSS CDGLIEKIRK TGVSKEMSFG
ARYEPCTSYF RKVMSLFRPA PPRTIADQQS MSITLSVNHP GVSREATKKT GGHASGINSL
CNKTDAAAFQ ALDPETLEPV GIASQQILHP DLNGPLSASH AKSDPVTGDV FNFNLALGRN
PIYRVFTVSA STGETSILAT IPGARAAYLH SFFLTENHVI LCVWNSFFAA GGIGILWHRN
IADAIADYDP SSPATWYVVD RRPGGRGLVA TYESDPFFCF HTVNAYEEPS PSDDGSVDVV
ADLTAYPNLD VIKLFYLSNI VSTSPDAGKF SKDNLGVYKR FRLSSLPTSS SSSSSSTKPK
RATLDFQVDA SITPELPTLN PFHVTHCHRY VYGVVATGKS SFLDGLVKFD TETKTAVSWS
EFGQNAGEPI FVPRVRKQAT GGEGEEVVEE DDGVLLTVVL DGLKGNSYLL VLDAKSMKEV
GRAEVAGAIG FGFHGTHVPA GKGRGLDF
//
