ID A0A2B7XD58_9EURO Unreviewed; 1679 AA.
AC A0A2B7XD58;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Guanine nucleotide exchange factor LTE1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AJ80_08118 {ECO:0000313|EMBL:PGH06701.1};
OS Polytolypa hystricis UAMH7299.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGH06701.1, ECO:0000313|Proteomes:UP000224634};
RN [1] {ECO:0000313|EMBL:PGH06701.1, ECO:0000313|Proteomes:UP000224634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH7299 {ECO:0000313|EMBL:PGH06701.1,
RC ECO:0000313|Proteomes:UP000224634};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH06701.1}.
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DR EMBL; PDNA01000176; PGH06701.1; -; Genomic_DNA.
DR STRING; 1447883.A0A2B7XD58; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000224634; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000224634}.
FT DOMAIN 376..504
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1432..1675
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 31..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1679 AA; 185915 MW; 0B8DB032F7881578 CRC64;
MERPSSTGAD ISLASLESDK RKVDFATVQD DNELTSKMSP GTSRLQDKQG LRRAHTVAQT
GNVSHKNNPS TRGARARTSS LRRVKDSSEV LRERSLKRLN QEKATSEGTG AIGGRQGIQF
TVGNVGHNGK IYLRPLMHPN STSSQPSTFV QPPQTFNEGY LRPAAPAEND HRYSIWSSSQ
LSELRPSIIR EDSAESRSSE LKYLHSAGTN DYRRYSLSTI DDHFPSNNRN ELRIVIERPE
PERPKSAGAP PVPSLEVPIP HFRLGGFRFT AEGTPMLRSS AYTRTSVSDN FRASAFAIKS
DFSMPMSSQA YEVIDPSRLH SFPPSMFTGS QAWTDLQSPA KQNSVFYKLK EPVDPRIFDS
LTTLKDDPSV VRYAKGTNEI SAATPARIVA QISSDSFMDY ELVSDFFLTF RSYLSLSNLM
SLLLARLEWA INRPEDDGRI VRIRVFAALR HWILNYFVDD FVVNRALRVQ FCSRINEMYE
DVKNRSNDSS SDLKILQDLK KCWNGRCSLY WDSPDLVSDS PDAKVVPGGV AGSRDIELNR
LSDARSWDTG IDAQTNITTT IPIYGQPVSE PVERLSRSYS HSRQLSTASA GDVPICASSV
RSLQAISCSL PAKRRSLHSG MARGPHPVMV SSRRHHSPAS SRNLATAPVI PIWRRPHHSH
KRSGSFSDSV RDDRAPLPQS NTEGSGGPLF QALPYAESLI RGNVFPPVEP YVNFLPPPSP
AFELSQLEFE SRSSVKQDAH KSAGPGMKTL IGSIKRAFHP RQSSSVSHSH KEILPSLKGK
TSTLPANVGF RSDAYRDKRS GPNTFTRVDV LCEEAAQSYR KLVVQETEKG SVVVEEETTP
RAKGKQPASA DAASSEAFLD PGMFSGRIPS HMTMGSKSIV IVDDTGFEIP LMSGALRLDL
NSSPLPQDAT GPSDIPTQQA STLVARSESP TPIYHEDRMP RSPSLALSEV NPELQERRSA
SVARSVSKRT VKSLSTRLRK YASYQSFSLS LARSSLSTVD HSLASAQPSQ DSSDRPFGRM
LRRRPGGDLR KVTNIHDLEP SPRPRSFASR TTQTDSMVES VISAARNRFS TYDSRGVGNR
EVPTGGRYSL APPRPSQLGR HSFEAAVAEF SQIPDDDDGG IESTLLKLEG KWEKPSPASS
PNKPAFPADL PAPAADSQDD GEETDKEKVH RHQHLLDPSV PVANQSNAAK NLSVISAPYT
ESVVESEDSY CSIPLLERGL SDDSMKSPQR SPTYPSAMTP SPLFNSQDVS AMDKQESSHP
SIDIVEKTES LKRIPQGSTL PMPPTRHSLS EQDTVNQSDE YDSELSSEIS VDVINRDEVV
DKPEGDVHVG RSMSFSNLGI LNNPLTHPPS PPMTLQHPNS MVSSLGATDS KTYHQRKPIT
PETSPIHKVV SDANRNPDVQ QFSSNILLKS ESQGRDDLPA IFGHVPFILA CDSQVLAQQF
TIVEKAALSE VDWKDLVDMR WGHTSQSTLN WADYLSKDDH KGIDMVIARF NLMVKWATSE
IVLTRNINER AQTIVKFIHV ALHARRILNY STMLQITIAL SSVDCTRLVK TWELVPNLEK
QLLKDMESLI QPIRNFHKLR REMETTNLQD GCIPFVGLYV QDLTYNAQKP AQIATTRDGE
PLVNFERYRT AATIVKSLLR LIDASTKYTF ESVDGIIERC LWVAALPDEK ITSLSKTIE
//
