ID A0A2B7XK76_9EURO Unreviewed; 2526 AA.
AC A0A2B7XK76;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN ORFNames=AJ79_05792 {ECO:0000313|EMBL:PGH08997.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH08997.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH08997.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH08997.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the THOC2 family.
CC {ECO:0000256|ARBA:ARBA00007857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH08997.1}.
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DR EMBL; PDNB01000096; PGH08997.1; -; Genomic_DNA.
DR STRING; 1447875.A0A2B7XK76; -.
DR OrthoDB; 179356at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0000347; C:THO complex; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR040007; Tho2.
DR InterPro; IPR021418; THO_THOC2_C.
DR InterPro; IPR021726; THO_THOC2_N.
DR InterPro; IPR032302; THOC2_N.
DR PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR Pfam; PF11262; Tho2; 1.
DR Pfam; PF11732; Thoc2; 1.
DR Pfam; PF16134; THOC2_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968}.
FT DOMAIN 134..874
FT /note="THO complex subunit 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16134"
FT DOMAIN 876..951
FT /note="THO complex subunitTHOC2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11732"
FT DOMAIN 1249..1554
FT /note="THO complex subunitTHOC2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11262"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..2526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1788..1894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1907..1990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2062..2076
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2078..2101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2102..2123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2221..2238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2279..2386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2387..2402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2403..2421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2427..2444
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2448..2476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2526 AA; 280857 MW; 1CF0D47B0A6BD38E CRC64;
MAPAAGGKRK RGDRSWSGDS GNDGLRPSPH RPGNLNLAQQ QQQNQFHGQG RDAQDNRGRG
GRRGSRGGNR NGTPARRGSD SYNSQQKESS PPSKSVLASP RDPPEQSHPN RTPSTPVPNT
APKSQVTSYA YDYLTKECLE SWTSTGKRNV IETGVNARKA EDSLVISSVY QEIIQSVFDG
RISAVDGGTA VKEIIGEEVA AEEAPNTDGV KAPSFDARTL FLDTLSIITD ADTSHPGLRT
FVLSTGISPA LMRAQLETPL LQSLGLIRDT FSRMGIRKQT NLLYRQSNYN LLREESEGYS
KLLTELFTTS NNEPPSAEVV EDTFERVKAM IGAFDMDVGR VLDVTLDVFA AVLVKQYRFF
VKFLRVSSWW PKEETFLRRY GGIAESGLPK WALPGSAGWS TTEEDREEAL RVNEERDRIF
WDRAREVGIR AFFEIGRNQS LSPDQLKSIS ELSNKSAEED DDTQKWIEQT GTLPPKGNRV
AAQLLGFKLR FYSSAARNAS DVLPDNLIYL AALLIKVGFI SLRDLYPHLW RPDESMDELK
EEKMKEKEQR ERAARPGAGT MNALMMAGAL TDDTLPVPTP RPREADTRAA TPAKDQDADK
AQAKAEENKD ALPEPADQKV LLLKSLLAIG ALPESLYILG RFPWLLDAYP ELPEYIHRII
HHSLSKLCGS SRPMSSRTDI KDQKKIVSGD HAGVPKGSLR LADAPPRRVL RWALLDKEDT
NDGTDYRFYW DDWTDNIPIC QTVDDVFALC GSFLNLSGVK IGQDPSLLTK LARLGNESLT
SDPSESNWTR WRDLCKRLLV PALSLTRANP GVVNEVFTLL SHFPREVRYS IYAEWYSGQT
SRLPDIKVAF DQARAETKDA LKRLSKTNIK PMARTLAKIA YANPGIVISV AINQIEAYEN
LIEVVVECAR YFTYLGYDIL TWSLINSLGQ KGRSRVQDGG LLTSRWLNAL ASFVGRVFKR
YSTIMDPIPV LQYVGDQLRQ NNSTDLVILE QLISSMAGIV TDTNFNDSQI QAMAGGQLLQ
SQTMLQLLDK RHESKNTSKR LMKSLSDSKL AGQLLIAIAQ ERATCIFRQS EADNELKLLG
NIFDEIHRVL TQYIDLLRSI FDVEQFDAFV PDVASLIGEF GLQPEVAFWI TRPSVAHQIG
EVDAKKREES ARKTESESAT PTAANSKSPD GDVEMADDGE AVENEETSGD VAMSTEESAP
NTNGTQSGAQ TNGPNTPAPP QTPSESVPWH PVLEGLMEKI KTTMPQSTWE VVGLPFYVTF
WQLSLYDIQV PQQAYEEELV RLKKRIQAIS QDRSDVSMAG TLKKDKEKKH INDLHDKILA
ENKAHIRAYG LSRGRLQKEK DRWFVGLRGK HEALNIAILE QCLLPRLLLS PIDAFYSFKM
LKYLHSSGTP NFRTVGFLDQ LFREQRLTAI IFQCTSKEAD NLGRFLNEVL RDLTRWHADK
AVYEKEAYGM KKDLPGFAMA VDQEGKPRSF LDYEDFRRIF YKWHRIFGAC LKTCLSGGEY
MHIRNAISVL KAVVQHFPAV NWIGRDMHTC VNNLKTLDPR EDVKIPAASL IGDLNRREKK
WMLPQAFMIV SLPTSNVKGR ANPPKNESLP GDKAKSRTPQ PQSTTPKSLN ASAPDFKPSG
TSTTTVNGAR PGKSEVEDGE IEDAKMAEAK RKNAAAKPEA TKADAQPQPV PDTSGSKETA
VSSKSEKAEQ AEKPAVTQEA QPAKPAEAAT APLQPASQPP SATPAPQTDA QNAAHGSESP
APSRVASRPP SETSHPPSIP KRPDVDRYAP QPSPPIRPQP NLPNRPEPPR SFRHDERMTM
RPPNIPDERR DARDTRHPDR IGRFGGSDRE RPFEHPLPVD PRAHGRPSDR DRLDGPRTDR
DFPPRPADDH FGRPSYRESR LPPRDQEWSD RMSRGRMSQA DAFQARQDSE RSFRDGDMHQ
YRHANLPEPH DRDHPTRLPH PDPGRHEPPR PERDDRRSRD SRPSSPPKID DSRPPNRPER
RDERDERKPA SFPSQPPSRP EDTPTGPRGD RPSHPSAGDN RHGQDSRSFP PSANPSYGRL
NQESRFPSRP QEPFDRPQDI PSGPRRTSSQ RAGRNPPLSQ PLPIPPQPSD RQPPTGPSNR
PPARNLPHQD QLAASTPSGP ASLEKLDTSG IHPDRLKAFQ SPSGDSPAPA LPPSGPRSDG
HPPSGSQSSN RGSSGTPLAG ERGRDKRFAG INNMLQQYGG PADKPGMGAS IRGRGANRAG
GNSMNVPSPQ STRPQTPVGP MGDSYPGTAP PPASDRPELF PTRSDVPPPP PPPAQEEPRG
HGRAGRRSEI IEEAAAESRR SPRHSSGTRT PDRERDRDRE RGRDRDREHR DRDRDGSRRG
EEDSARASAK RDEYRERERH RDSDRERDRG RATETSSRDQ ARGSRDSSSR RGAQSSSVNR
EPISSSRRRD KRDRDTATHD TPSRGGKPVL SPPPPPPPPP PSSELEDRRW SSGGRGDDRN
RDRERERDRD RRDMGNGRGG NSGAANGGGT WPRKRGRPTG GSVDDGHNGA GPTRAGGENK
RPRRGH
//
