ID A0A2B7XKI0_9EURO Unreviewed; 971 AA.
AC A0A2B7XKI0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=AJ80_06768 {ECO:0000313|EMBL:PGH12254.1};
OS Polytolypa hystricis UAMH7299.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGH12254.1, ECO:0000313|Proteomes:UP000224634};
RN [1] {ECO:0000313|EMBL:PGH12254.1, ECO:0000313|Proteomes:UP000224634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH7299 {ECO:0000313|EMBL:PGH12254.1,
RC ECO:0000313|Proteomes:UP000224634};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|ARBA:ARBA00008842}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH12254.1}.
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DR EMBL; PDNA01000120; PGH12254.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7XKI0; -.
DR STRING; 1447883.A0A2B7XKI0; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000224634; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF216; OXYSTEROL-BINDING PROTEIN HOMOLOG 3; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000224634};
KW Transferase {ECO:0000256|ARBA:ARBA00022676};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 213..307
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 42..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 897..924
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 395..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 108130 MW; DE0048EFB5EC6CF5 CRC64;
MAGMEELEIH SKSYLVRWVN VKSNHTISWS IQPHKKSLNF GIFKHPGHGP TAPPTSSNHE
VKEDLNKENQ KAANSSSAVT EKLKNIGLKP IQWIGKCEAD KISQGTYDVE LNEGGNYALV
IDNTFSKQIS KTATFVLLTY PSHAPPQSGH QVHHSQVLAG LTGVQAANRS TTNIAAGPSD
STESLRQNRP WAWSISGARP PPRSSDSSRS FPLTVHTGVL QKRRRKRHQG YARRFFSLDF
TSSTLSYYHD RNSSALRGAI PLALAAIATN DNTREISIDS GVEIWHLRAL TENDFRAWKH
ALEKASKPQD AAPSTSEPRL RIQTEALQRV PSFATESRDW TEVEALVEKV TRSRDMVRRL
AQDTDPKYLS TPIERRGRSR SPGAKSTRNA VEANGDENGE TKERRSFWKL KPKDNNIISS
SALKRNVSSQ HLPSPASTDS HSIGKGLVES PARVEHIHDD LMALLRDLNT VVTEFSTLLT
DRKHNRLSVP PSAKPRASFE SDMSQEFFDA VDGKLSPLLT IQGDSDDEGK SVMEDRTDEE
ESLSGSDVDE SDTFITSGLR LDTSSSLFPA KPRSLVPLPL SSVSRRMKIP PPTVMPPSLI
GFLRKNVGKD FSTISMPVSA NEPLSLLQKA AEQFEYSQLL DKATSATEGL ERLLYVTAFA
ISILSNNRVK ERIIRKPFNP MLGETYELVR EDKGFRFIAE KVSHRPVQLA FHADAKDWSF
AQSPKPSQKF WGKSAEIITE GKARLTLHSS GEHFSWSNAA SFLRNIIAGE KYVEPVGEMC
VLNETTGQKT ITTFKAGGMF SGRSEEVSVK AFDTHGEELP LGLEGTWTGA LQLTQHGNQT
NKTIWSAGSL VDKAAKHYGL TTFAACLNEI TPIEDAKLPA TDTRLRPDQR ALEQGDVDGA
EDLKAQLEER QRERRREMEE AGDSWRPRWF TKVDPDNGCE EEVWKIRTGK DGYWEERAKG
TWTGTLNVFQ L
//
