ID   A0A2B7XMW9_9EURO        Unreviewed;       541 AA.
AC   A0A2B7XMW9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Pseudouridine synthase RsuA/RluA-like domain-containing protein {ECO:0000259|Pfam:PF00849};
GN   ORFNames=AJ79_05424 {ECO:0000313|EMBL:PGH10496.1};
OS   Helicocarpus griseus UAMH5409.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX   NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH10496.1, ECO:0000313|Proteomes:UP000223968};
RN   [1] {ECO:0000313|EMBL:PGH10496.1, ECO:0000313|Proteomes:UP000223968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH10496.1,
RC   ECO:0000313|Proteomes:UP000223968};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH10496.1}.
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DR   EMBL; PDNB01000086; PGH10496.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7XMW9; -.
DR   STRING; 1447875.A0A2B7XMW9; -.
DR   OrthoDB; 5479603at2759; -.
DR   Proteomes; UP000223968; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02557; PseudoU_synth_ScRIB2; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   NCBIfam; TIGR00005; rluA_subfam; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF40; PSEUDOURIDYLATE SYNTHASE RPUSD2; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000223968};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          133..328
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
FT   REGION          255..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        177
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ   SEQUENCE   541 AA;  59494 MW;  0E0BAACF995D822C CRC64;
     MALTTVDNTI SVGEKEVLEP PPDVVVTPCD PLPRPYYIEG GLRRVAPYHY TYNTFCKERW
     RGRGLLDVFG SEFRDRPKEY YKNAIENGAV CINGKPASID TKIKNGDVIS HTLHRHEPPV
     TSQPIGIIHE DTDMIVIDKP AGVPVHPAGR YNYNSILEIM KAERGNGWVP YPCNRLDRLT
     SGVMFIGNHP KGAEQIGEKL RSRTVRKEYV ARVKGKFPDG VVLCDQPMLK ISPILGLNRA
     RASGKEARTK FRRLAYYPPR KPEEKTSNSP ARPATPPATL PDEMNISPAD TPAGASTPVP
     MAPDEEGYSI VHCLPLTGRT HQLRVHLQYL GHPITNDPIY SNRRVFGHSL GKADASGDND
     EQIIYRLSKM GKTEPADSLS YQTFQTPPPE SVSKNDPAVV DGLLAKEHEV MVNDYLKRKG
     EKMNGKQCET CGTDLYTDPG VHELGIFLHA IAYADVTGAW KYKSKMPGWA MPPDGMEGPT
     ACPDWVEDDE KDEIIGKGQH GDAALVEGLG TVNLKDLISG NKAGSQVTAE RNGDVDGADG
     N
//