ID A0A2B7XQ07_9EURO Unreviewed; 1116 AA.
AC A0A2B7XQ07;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Sodium/hydrogen antiporter {ECO:0000313|EMBL:PGH13854.1};
GN ORFNames=AJ79_03422 {ECO:0000313|EMBL:PGH13854.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH13854.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH13854.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH13854.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH13854.1}.
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DR EMBL; PDNB01000041; PGH13854.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7XQ07; -.
DR STRING; 1447875.A0A2B7XQ07; -.
DR OrthoDB; 1607026at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..433
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 458..1005
FT /note="Alkali metal cation/H+ antiporter Nha1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08619"
FT REGION 453..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 122635 MW; E2234273984C56C4 CRC64;
MAWDHLSIDK PHLAYMILGG FTSLFMLCSL FVKEKLYIGE ATVATLCGVI FGPHAANLFD
PISWGNVDKI TLECSRIVLV VQCFAIGVEL PKSYMERHWK SVTLLLLPVM TWGWLITSLF
IWWMIEPLSW LESLACAACV TATDPVLASS VVGKGKFAKR VPKHLRDLLS AESGCNDGMA
FPFIYLAVYI IEYKSRPNQV ALHWFCYTIL YECVAGAIFG FTIGYIGRHA IKFAERKSLI
DRESFLSFYF VLALFCAGSG SLLGMDDLLI GFSAGVGFSN DGWFTEKTEE AHVSNVIDLL
LNLTYFVYFG AIIPWQQFDA PDLGLVPWRL VVIAIFVIFF RRVPIMLALK PFIPDVKTWR
EAMFAGHFGP IGVGAIFAAI LTRAELEGGS TQPFAVLPKP GDHNYLVVSI IWPVTTFIVI
SSIIVHGSSI AVFTLGKRIN TLTITMSYTQ ADDEGPSWMN RLPRIQSQSK GSLLSRKDSM
EMESNEKLPE FPPGTLGPIG FAGNLLRRQK EDAESEPNSR ASSRRPSRRK RIGAGGPVSQ
SAIMPQRRPD ITSPTQGEAL DENQPPQESP QSTTGETRAG EGRRELIQEP ELEAYREGNK
MVIEDEEGNV LETTDVKNFT PEQQNDRIRQ QHKRVRSDRS GDVAKSKTHP HEKTEGENAE
NVVGDKMGHP YDKIKKRLPA WMGVGKGPKE PEAGPSTQKP KMDTRRSARA YQFGNTIIVE
DADGEVIKKY TIPHPEKAPK DLEAAGASSS PDVKLTSSPE PEPMRRKMSR VGTWMGLGGD
AKQGGESSKK PQQAERDSLD DDRLRFTVTR PDLMARPDLG RRMSKQDFID QLRGLDHKTR
VDLLHHHSTP EQLRAALQRK DSSRPPPPQQ PTIPEVYSPP THESEPGGEE DQAVPTHDVA
ASLAQYSGHM TSAAEERRRR LMAASGDDAG GESSSSHSPT TRPRRDSEDD GTERIPPSQL
RQMAGVRPTT ASSSSRAVHD TAETPAERRR RMAALGATDD DDDGDEDDSG RGRGAIVEDS
DSEDDGRPRA VKGKVQFADG TRPARKKGAA GDVVTVPPSA YVLPRSAGDG SRDNGNENRA
TGGLSERGGN GNGNGNGSGR GHVQRVSWGG ETGRDS
//
