ID A0A2B7XRW2_9EURO Unreviewed; 869 AA.
AC A0A2B7XRW2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AJ79_04878 {ECO:0000313|EMBL:PGH11503.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH11503.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH11503.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH11503.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH11503.1}.
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DR EMBL; PDNB01000072; PGH11503.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7XRW2; -.
DR STRING; 1447875.A0A2B7XRW2; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968}.
FT DOMAIN 2..435
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 215..299
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 469..666
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 164..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 96532 MW; 968F918FD1D5D812 CRC64;
MPGFADSFWT PDYASGLSVL LTKLQQGIVE NQQILTIANM RAAAEEQYSA KLGEIAPAID
RMPNGFTKDD GASVRKAYEG IRSEMMEATK SHAKIAQSIR ELVVNPFSRW AAQHEVRILH
SQEDLQVRIR EHHKQSEVVS KLRTQYFNKC RLVEDLEEEN KLAFQSPVKD GPGSPKAQPP
PPTIVLPDAS EDQDPVELGD IMYPPEQIKK LLTQMLENIP TKETRFPILG SYQNTSTGAD
IVDFIQRHME ASSVSYAERI GQDLVDNGFL RLVGNVGSTF ANSSKMNYQW RAKAFKLTGI
PEKKKGLSRV SSMGSAGEDT ADSPTATAVA DLFSGWKLNN AFPNETHADK LRRESRDADE
RYKAAVKKLD RLRCHLEEEM VDYLKFMEQC ELDRLKAIKA VVLDFSGAVS NVVPSLRSTV
DKMMLYQETI QPLGDLRYLL ENYRTGAFVP RVQAYENYYG TVDDQTFGVD LEARARADRK
RVPIIVTTIL TYLDNHYPDL EGDEARRAIW LHEVPLNITH HLRNALNSGK PFTHDVLEKY
EIPVVANVLK LYLLELPDSL VSSQVYEIIR TVYTTASEAP EEGRVKVLQS TLGQLRLNNI
ATLDAIITHF TRLIDLTSAD EVYIAALATT LAPCVLRPRL ENNLTMDERH SYRLVRDLFE
HKDDIFGELK RQSGNAGTLG PPGHRPRAIS TDESNRRANM EARQRAIVSR SRANSPAPTN
RHRRDKSTGG SESTRFPINV TSPPASVTER RPPRHSLEVP GSADSSPATD RAAKPLPSTT
ALRDSIVTNG SGDHTATDSI SSTTTLTDPV AAPPKDGEGV EKSNSLSRSG GRYSRITGGL
KRDSMTESEK DSPTGAVPGV TLKDAPMDD
//
