ID   A0A2B7XRY4_9EURO        Unreviewed;       635 AA.
AC   A0A2B7XRY4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=AJ80_07001 {ECO:0000313|EMBL:PGH11740.1};
OS   Polytolypa hystricis UAMH7299.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX   NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGH11740.1, ECO:0000313|Proteomes:UP000224634};
RN   [1] {ECO:0000313|EMBL:PGH11740.1, ECO:0000313|Proteomes:UP000224634}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH7299 {ECO:0000313|EMBL:PGH11740.1,
RC   ECO:0000313|Proteomes:UP000224634};
RA   Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT   "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PGH11740.1}.
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DR   EMBL; PDNA01000128; PGH11740.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2B7XRY4; -.
DR   STRING; 1447883.A0A2B7XRY4; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000224634; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF29; PHOSPHOTRANSFERASE; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000224634};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          43..283
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          295..491
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   DOMAIN          571..630
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   REGION          533..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  69072 MW;  09C756CFCC27E648 CRC64;
     MSYSSAIDDL DQGMDHESLI GQDMEQEPED TQRDIISEQD EKVNNFIQPL VLEVGRLYQL
     AGRFSKVYGD LARTSEQQFL PTPVTRLPTG QETGRYLAID VGGTNLRVAF IELLADGGNA
     AESEDGVSST KSRETMLKAQ KQRVRRSLEK AWPIGEHLKM DKAEDLFLWI GDCMAEVVAD
     SLADDFAQGN HVPEELEMGI TFSFPMMQDS LSEATLMPMG KGFAITSDLN LGSILLAGYE
     RHTRRPYVPD EPSAKRRKLF ALPRLKIAAI TNDTVATLAA LAYLVKSLPN SRVAMGIIVG
     TGCNATIPMN LADLRESKAR HITSRHPDAV ETVVNTEWTL GGAAPPLREL NITTKWDMQL
     DQACARPGFQ PFEYMTGGRY IGELIRLIFF DYLTSVIGVS KQDLPSKLVQ EYAITTAYLS
     SVVAQPFSDD ALLDKLNTTL PPPESSSWSW DLECTRAFRK VARAVQTRSA GLIAAAVVGL
     LACKNEIKLR DDGATNSHQR STNIVVPSIN GTIDLSSATA TATSNVRIFT SGSTPSISQN
     SSHGAARGAG NGRTVQQSLE PAPSDWCSGP EELVVAYTGG IIQKYPHFKE TCQRYIDRLV
     IWDGPQESGK SVFLREASDG GIIGAGVLAG MVSGG
//