ID A0A2B7XS61_9EURO Unreviewed; 1501 AA.
AC A0A2B7XS61;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=AJ80_06957 {ECO:0000313|EMBL:PGH11799.1};
OS Polytolypa hystricis UAMH7299.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Polytolypa.
OX NCBI_TaxID=1447883 {ECO:0000313|EMBL:PGH11799.1, ECO:0000313|Proteomes:UP000224634};
RN [1] {ECO:0000313|EMBL:PGH11799.1, ECO:0000313|Proteomes:UP000224634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH7299 {ECO:0000313|EMBL:PGH11799.1,
RC ECO:0000313|Proteomes:UP000224634};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH11799.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PDNA01000127; PGH11799.1; -; Genomic_DNA.
DR STRING; 1447883.A0A2B7XS61; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000224634; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000224634};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1501
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012654238"
FT TRANSMEM 1358..1380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1410..1434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..672
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 708..1347
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1501 AA; 168718 MW; FCD59E3FF57FD8AD CRC64;
MILRRLLLAA AATLLAASIP STTAKSSEPK ISSSKFDNEP SSLFYFEDTD TVLFQDAREG
NIHISTNAGD SWDRVKGPDG AIKGQAWALW PHPHDKKRAY VLGKKKKHWV TEDAAESWRE
FEADIELSSL RSPLVFHGKD SDKVVLQGQQ CDGILCESKI YYTTDGFKTV KKLVDGAREC
MWAVVSPIFG EGNDNADKID NRIFCIMPGL HSPWTKDNRL LFSDKFFEDD GTEAPLNDGR
AVSGILRTAG VKRYLLAVTK SERTSELALY VTNDGDKWHR AQFDGQRLEE DAYTLLESTN
HSIQIDVMST KNSNPMGTLF SSNSNGRYFT RNIEHMNRNT HGYVDFEKIA GIQGIALVNV
VDNWEEVEKS FNADKKIVSR ITFDDGRTFQ PLKVKDDDLH LHSVTDIANS GRVFSSPAPG
LVMGVGNTGK RLKDYNDGDL YVSDDAGITW RKALEDAHKY EFGDQGSVLV AVYDEGRTEK
ISYSLNHGKD WKSAELPHKI RARQLTTTPD STSLKFILVG TSKDSDKTYI MSIDFTDMQG
KCGKDDFENW PARLNEKEEP DCLMGRQQFY RRRKADAKCF IDSDFKDPVP EFKPCKCTAE
DFECDFNFVR SEDRKECVPA RTLPVPEGEC KKPEDEYTGS SGWRLIPGNE CIRDGGEELD
KEVKRPCKDT EKKPVTGDIA VEKTFFSADQ FRDYFYLERT DTNTGDDETL MMLTSEQQIY
MSKDHGKKWK EILEGEGVSR VVPHKYDNEA VYFLTNSKEG FYTIDRGDSF HPFKTELSPN
RDKLPVLAFH PDHRDWLIWT GADECEGSGD CHSTAMYSIN RGADWATLMR YVRRCEFIKR
EGRDSSDKLV FCEQYEDENL KNRRVQLLST DNWFEHKTKH FDDIIDFATM SEFIIVAARA
ENQKSLKVDA SVDGKTFAEA EFPANFDVPY QQAYTVLDSS THSVFLHVTV NNMEDHEYGS
IIKSNSNGTS YVLSIGGVNR NSPGYVDFEK MQGLEGVAIV NIVANVEEVE KGGAKKLKTS
ITHNDGAEWS QLPPPEKDAE GRAFDCKTKN GKPTEKCSLH LHGYTERRDP RDTYGSPSAV
GLMMGIGNVG EFLGLRSEAD TFITRDGGIS WHTVKKGNYQ WEYGDQGSII VIVPESKPTK
SLLYTLDEGE TWKEFEFSEV EMQIDDISTV PSDTSRGFLL WGKEVGSGAK SGVATVALDF
SGLKERSKKC VLREEDPEAD DYYLWNPKHP MQEDNCLFGH VEQYHRKRPE KDCYNGRELQ
HLDKYAKTCE CTRQDYECDY NYEPEKGGSC RLVPGLSPPN PMEVCKDDPN AVEYYEPTGY
RRIPITTCEN GLQLDRIKAH PCPGKDEEFE KKHPRLSAVG LFFAIALPLA AAGLIGWYIF
THWDGKFGRI RLGEGSSFSR NSGGIFDRDS LLISIPVAIV AGVVAFVAAI PLVISSLWRS
ASGYVRVPGS GGGFRGRSGA GRPYASRGAF AARRGDYVGV VDDEDELLGA DEGDEDGDEE
V
//
