ID A0A2B7XU36_9EURO Unreviewed; 719 AA.
AC A0A2B7XU36;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE RecName: Full=Alpha-actinin {ECO:0008006|Google:ProtNLM};
GN ORFNames=AJ79_04349 {ECO:0000313|EMBL:PGH12283.1};
OS Helicocarpus griseus UAMH5409.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Helicocarpus.
OX NCBI_TaxID=1447875 {ECO:0000313|EMBL:PGH12283.1, ECO:0000313|Proteomes:UP000223968};
RN [1] {ECO:0000313|EMBL:PGH12283.1, ECO:0000313|Proteomes:UP000223968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH5409 {ECO:0000313|EMBL:PGH12283.1,
RC ECO:0000313|Proteomes:UP000223968};
RA Munoz J.F., Mcewen J.G., Clay O.K., Cuomo C.A.;
RT "Comparative genomics in systemic dimorphic fungi from Ajellomycetaceae.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PGH12283.1}.
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DR EMBL; PDNB01000060; PGH12283.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2B7XU36; -.
DR STRING; 1447875.A0A2B7XU36; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000223968; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd21215; CH_SpAIN1-like_rpt1; 1.
DR CDD; cd21291; CH_SpAIN1-like_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000223968};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 77..182
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 191..297
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 551..586
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 82157 MW; DEFA0E798CD81866 CRC64;
MPLPPQLIHH NHHHHISSSP LSPPPHYPHH YSSPLLSPLR TLTHYRCLRS SSYLYNHRRT
GIGSPSRVML EEKQWITVQQ KTFTKWLNNK LKARDQAIDD LVKDLSDGVI LIHILEILGN
ECLGRYASKP KLRVQKFENV NKSLDYIKGR GIQMTNIGAE DIVDGNRKII LGLIWTLILR
FTISDISEEG MTAKEGLLLW CQRKTACYPG VEVRDFSASW NDGLAFCALL DIHRPDLIDF
DSLDKNDHKG NMQLAFDIAS NDIGIPDLLD VEDVCDVAKP DERSLMTYIA YWFHAFSQLE
RVENAGRRVE KFVMNMQGAW EMQNSFERRM RELLQAIRAQ RAEWRESSFE GTYADAKEQA
AKFSAYKRNQ KRKWVAEKSD LAALLGNIKT KLSTYRLRAY EPPPELALEV LDQEWSALTQ
NERERSQLIN ETIRDIKNAL RRSFADKAND FALTLNTLSL AISGLEGDVE DQLSHVQRLN
DNLPPLDAFL ETIADLEERC IEANIEENDF TTYTLDELAY ELGLVKSSVS KKLAFLENQT
VARNMTNLTP IQLEEFESVF RHFDRDSSNT LQEIEFSAAL ASLGLVYDED EMHEVFVETC
GPGRIERNAG VSFEQFIRFM VSVTEDQNTA EQVFQSFKEV ADGKPYVTEL DLRHSLIPDE
LIENLLETMP VHEGPDLLED RDVPKYDYIT FMEKMMDEGG DGGDGRGGGY NGHRSANGL
//
